Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds.
Biocompatible Materials
/ therapeutic use
Caproates
/ chemistry
Cell Proliferation
Cells, Cultured
Epithelial Cells
/ cytology
Humans
Kidney Failure, Chronic
/ surgery
Kidney Tubules, Proximal
/ cytology
Lactones
/ chemistry
Polymers
Tissue Engineering
/ methods
Tissue Scaffolds
Transplants
/ growth & development
polycaprolactone
regenerative medicine
renal replacement therapy
renal transport
tissue engineering
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
25
10
2018
pubmed:
15
12
2018
medline:
27
11
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
The increasing prevalence of end-stage renal disease and persistent shortage of donor organs call for alternative therapies for kidney patients. Dialysis remains an inferior treatment as clearance of large and protein-bound waste products depends on active tubular secretion. Biofabricated tissues could make a valuable contribution, but kidneys are highly intricate and multifunctional organs. Depending on the therapeutic objective, suitable cell sources and scaffolds must be selected. This study provides a proof-of-concept for stand-alone kidney tubule grafts with suitable mechanical properties for future implantation purposes. Porous tubular nanofiber scaffolds are fabricated by electrospinning 12%, 16%, and 20% poly-ε-caprolactone (PCL) v/w (chloroform and dimethylformamide, 1:3) around 0.7 mm needle templates. The resulting scaffolds consist of 92%, 69%, and 54% nanofibers compared to microfibers, respectively. After biofunctionalization with L-3,4-dihydroxyphenylalanine and collagen IV, 10 × 10
Identifiants
pubmed: 30548802
doi: 10.1002/mabi.201800412
pmc: PMC7116029
mid: EMS94321
doi:
Substances chimiques
Biocompatible Materials
0
Caproates
0
Lactones
0
Polymers
0
caprolactone
56RE988L1R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1800412Subventions
Organisme : European Research Council
ID : 647426
Pays : International
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : 022.006.003
Pays : International
Organisme : FP7 Ideas: European Research Council
ID : 647426
Pays : International
Organisme : University Medical Center Utrecht-Technical University Eindhoven
Pays : International
Informations de copyright
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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