Regulatory B cells and advances in transplantation.
B cell
immunomodulation
signal transduction
therapeutic strategy
transplantation tolerance
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
19
05
2018
revised:
03
10
2018
accepted:
14
11
2018
pubmed:
15
12
2018
medline:
6
5
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand-receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL-10. In experimental animal models, the extensively studied IL-10-producing B cells have shown unique therapeutic advantages in the transplant field. In addition, adoptive transfer of B cell subsets with regulatory activity may reveal a new approach to prolonging allograft survival. Recent clinical observations on currently available therapies targeting B cells have revealed that Bregs play an important role in immune tolerance and that these cells are expected to become a new target of immunotherapy for transplant-related diseases.
Identifiants
pubmed: 30548970
doi: 10.1002/JLB.5RU0518-199R
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
657-668Informations de copyright
©2018 Society for Leukocyte Biology.