Effects of antiepileptic drugs on cortical excitability in humans: A TMS-EMG and TMS-EEG study.
Adult
Anticonvulsants
/ pharmacology
Carbamazepine
/ pharmacology
Cerebral Cortex
/ drug effects
Cross-Over Studies
Double-Blind Method
Electroencephalography
/ drug effects
Electromyography
/ drug effects
Evoked Potentials
/ drug effects
Healthy Volunteers
Humans
Male
Pyrrolidinones
/ pharmacology
Tiagabine
/ pharmacology
Transcranial Magnetic Stimulation
/ drug effects
Young Adult
TMS-evoked EEG response
brivaracetam
carbamazepine
electroencephalography
excitability
human cortex
tiagabine
transcranial magnetic stimulation
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
28
07
2018
revised:
21
09
2018
accepted:
17
10
2018
pubmed:
15
12
2018
medline:
9
4
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
Brain responses to transcranial magnetic stimulation (TMS) recorded by electroencephalography (EEG) are emergent noninvasive markers of neuronal excitability and effective connectivity in humans. However, the underlying physiology of these TMS-evoked EEG potentials (TEPs) is still heavily underexplored, impeding a broad application of TEPs to study pathology in neuropsychiatric disorders. Here we tested the effects of a single oral dose of three antiepileptic drugs with specific modes of action (carbamazepine, a voltage-gated sodium channel (VGSC) blocker; brivaracetam, a ligand to the presynaptic vesicle protein VSA2; tiagabine, a gamma-aminobutyric acid (GABA) reuptake inhibitor) on TEP amplitudes in 15 healthy adults in a double-blinded randomized placebo-controlled crossover design. We found that carbamazepine decreased the P25 and P180 TEP components, and brivaracetam the N100 amplitude in the nonstimulated hemisphere, while tiagabine had no effect. Findings corroborate the view that the P25 represents axonal excitability of the corticospinal system, the N100 in the nonstimulated hemisphere propagated activity suppressed by inhibition of presynaptic neurotransmitter release, and the P180 late activity particularly sensitive to VGSC blockade. Pharmaco-physiological characterization of TEPs will facilitate utilization of TMS-EEG in neuropsychiatric disorders with altered excitability and/or network connectivity.
Identifiants
pubmed: 30549127
doi: 10.1002/hbm.24448
pmc: PMC6865504
doi:
Substances chimiques
Anticonvulsants
0
Pyrrolidinones
0
Carbamazepine
33CM23913M
brivaracetam
U863JGG2IA
Tiagabine
Z80I64HMNP
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1276-1289Subventions
Organisme : German Research Foundation
ID : DFG ZI 542/9-1
Pays : International
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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