More expression, less function: cleaved dynamin in glomerular kidney disease.
Bis-T-23
Cdc42
GTPase
Rac1
RhoA
dynamin
glomerulus
kidney
podocyte
proteinuria
Journal
The Journal of pathology
ISSN: 1096-9896
Titre abrégé: J Pathol
Pays: England
ID NLM: 0204634
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
15
11
2018
accepted:
10
12
2018
pubmed:
15
12
2018
medline:
4
7
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
The role of dynamin in regulation of kidney filtration barrier is well documented. Dynamin binds to and produces filamentous actin, which is a key component of healthy podocyte foot processes (FPs). Destruction of dynamin, for example by cathepsin L, leads to loss of a functional actin network and uncoordinated membrane signaling, a situation that allows for effacement of FPs and proteinuria. Now, Khalil et al have examined the dynamin expression in kidneys of proteinuric animal models as well as in kidney patients and produced data that further clarifies the role of dynamin in glomerular and tubular proteinuria and may aid in pinpointing patients who are affected by loss of dynamin function and may benefit from appropriate therapeutic approaches. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Substances chimiques
Dynamins
EC 3.6.5.5
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
413-415Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.