Getting TANned: How the tumor microenvironment drives neutrophil recruitment.
cancer
chemokines
chemotaxis
leukocyte tumor interactions
monocytes/macrophages
neutrophils
signal transduction
signaling cascade
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
20
07
2018
revised:
20
10
2018
accepted:
16
10
2018
pubmed:
15
12
2018
medline:
19
10
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
The directed migration of neutrophils to sites of injury or infection is mediated by complex networks of chemoattractant-receptor signaling cascades. The recent appreciation of neutrophils as active participants in tumor progression and metastasis has drawn attention to a number of chemokine-receptor systems that may drive their recruitment to tumors. However, the dynamic nature of the tumor microenvironment (TME) along with the phenotypic diversity among tumor-associated neutrophils (TANs) call for a more comprehensive approach to understand neutrophil trafficking to tumors. Here, we review recent advances in understanding how guidance cues underlie neutrophil migration to primary and secondary tumor sites. We also discuss how the presence of other myeloid cells, such as functionally diverse subsets of tumor-associated macrophages (TAMs), can further influence neutrophil accumulation in tumors. Finally, we highlight the importance of hypoxia sensing in localizing TAMs and TANs in the tumor niche and provide a cohesive view on how both myeloid cell types shape TME-associated extracellular matrix organization, which in turn contribute to tumor progression.
Identifiants
pubmed: 30549315
doi: 10.1002/JLB.3RI0718-282R
pmc: PMC8193910
mid: NIHMS1700042
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
449-462Subventions
Organisme : Intramural NIH HHS
ID : ZIA BC011216
Pays : United States
Informations de copyright
©2018 Society for Leukocyte Biology.
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