Effects of apolipoprotein E on nutritional metabolism in dementia.
Journal
Current opinion in lipidology
ISSN: 1473-6535
Titre abrégé: Curr Opin Lipidol
Pays: England
ID NLM: 9010000
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
15
12
2018
medline:
23
2
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
Various groups have explored the effect of apolipoprotein E (APOE) on neurodegeneration through nutritional and metabolic alterations. In this review, we hope to summarize recent findings in humans as well as preclinical APOE models. Metabolic pathways including lipid metabolism appear to play a large role in the pathophysiology of Alzheimer's disease. Carrier status of the E4 variant of the APOE gene is the strongest genetic risk factor for Alzheimer's disease, and increasing evidence suggests that E4 carriers may respond differently to a host of dietary and metabolic-related treatments. A new appreciation is forming for the role of APOE in cerebral metabolism, and how nutritional factors may impact this role. Considering the role dietary factors play in APOE-associated cognitive decline will help us to understand how nutritional interventions may facilitate or mitigate disease progression.
Identifiants
pubmed: 30550413
doi: 10.1097/MOL.0000000000000566
pmc: PMC6524767
mid: NIHMS1022630
doi:
Substances chimiques
Apolipoproteins E
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-15Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103527
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM127211
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060056
Pays : United States
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