Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3.
Antivirals
Human parechovirus
Picornaviruses
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
27
11
2018
accepted:
11
12
2018
pubmed:
15
12
2018
medline:
11
2
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
Parechoviruses A (HPeV, Picornaviridae) are neglected human pathogens that cause sepsis-like illness and severe neurological complications in infants. There are no antivirals available for the treatment of HPeV infections. We here report on cell-based assays that allow for medium-throughput antiviral screening of compound libraries against HPeV. The nucleoside viral polymerase inhibitor 2'-C-methylcytidine was identified as being an in vitro replication inhibitor of HPeV1 and HPeV3 that can serve as a reference molecule for further antiviral studies.
Identifiants
pubmed: 30550798
pii: S0166-3542(18)30713-7
doi: 10.1016/j.antiviral.2018.12.009
pii:
doi:
Substances chimiques
Antiviral Agents
0
Nucleosides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-53Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.