Clinico-pathological characteristics among South African women with breast cancer receiving anti-retroviral therapy for HIV.
Adult
Age Distribution
Aged
Anti-HIV Agents
/ therapeutic use
Breast Neoplasms
/ epidemiology
CD4 Lymphocyte Count
Case-Control Studies
Comorbidity
Female
HIV Infections
/ blood
Humans
Ki-67 Antigen
/ metabolism
Middle Aged
Neoplasm Grading
Neoplasm Staging
Receptor, ErbB-2
/ metabolism
Receptors, Estrogen
/ metabolism
Receptors, Progesterone
/ metabolism
South Africa
/ epidemiology
Viral Load
Anti-retroviral therapy (ART)
Breast cancer
Human immunodeficiency virus (HIV)
Journal
Breast (Edinburgh, Scotland)
ISSN: 1532-3080
Titre abrégé: Breast
Pays: Netherlands
ID NLM: 9213011
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
08
11
2018
revised:
04
12
2018
accepted:
06
12
2018
pubmed:
15
12
2018
medline:
29
5
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
Breast cancer is the most common cancer in women and a leading cause of cancer-related mortality worldwide. South Africa has the largest global burden of HIV infection and the largest anti-retroviral treatment (ART) program. This study aimed to analyse the association of HIV and ART use with breast cancer clinico-pathological characteristics. Study participants were females, newly diagnosed from May 2015 through September 2017 with invasive breast cancer at two academic Surgical Breast Units in Johannesburg, South Africa at the Charlotte Maxeke Johannesburg Academic Hospital and Chris Hani Baragwanath Academic Hospital. We compared HIV-positive and HIV negative patients' demographic and clinical-pathological characteristics at the time of breast cancer diagnosis. Of 1050 patients enrolled, 1016 (96.8%) had known HIV status, with 226 (22.2%) being HIV positive. HIV positive patients were younger (median (IQR) age 45 (40-52) years), than HIV-negative patients (median (IQR) age 57 (46-67)) (p < 0.001). HIV positive patients were more likely to be diagnosed with late stage breast cancer (p = 0.01). However, HIV positive patients receiving ART at the time of breast cancer diagnosis were less likely to present with metastatic disease than those not on ART (p = 0.05). HIV-positive patients present with breast cancer at a younger age and later stage disease than HIV-negative patients. Neither the duration of HIV infection nor ART use was associated with clinico-pathological characteristics of breast cancer.
Identifiants
pubmed: 30550925
pii: S0960-9776(18)30334-5
doi: 10.1016/j.breast.2018.12.005
pmc: PMC6369009
mid: NIHMS1516499
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Ki-67 Antigen
0
MKI67 protein, human
0
Receptors, Estrogen
0
Receptors, Progesterone
0
ERBB2 protein, human
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-129Subventions
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA192627
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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