Synthesis, photodynamic activities, and cytotoxicity of new water-soluble cationic gallium(III) and zinc(II) phthalocyanines.

Cell Line Gallium / chemistry Humans Indoles / chemical synthesis Isoindoles Photochemotherapy Photosensitizing Agents / chemical synthesis Solubility Zinc / chemistry
PDT Phthelocyanine Singlet oxygen Water-soluble

Journal

Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788

Informations de publication

Date de publication:
03 2019
Historique:
received: 26 09 2018
revised: 19 11 2018
accepted: 21 11 2018
pubmed: 15 12 2018
medline: 20 3 2020
entrez: 15 12 2018
Statut: ppublish

Résumé

The cationic Ga(III) and Zn(II) phthalocyanines carrying N-methyl-pyridinium groups at eight peripheral β-positionshave been synthesized. These complexes are highly soluble in dimethyl sulfoxide (DMSO) and moderately soluble in water and phosphate buffered saline (PBS); both Ga(III)Cl and Zn(II) complexes have shown no aggregation in water up to 1.2 × 10

Identifiants

DOI: 10.1016/j.jinorgbio.2018.11.013 PMID: 30551005
pubmed: 30551005
pii: S0162-0134(18)30573-7
doi: 10.1016/j.jinorgbio.2018.11.013
pii:
doi:

Substances chimiques

Indoles 0
Isoindoles 0
Photosensitizing Agents 0
Gallium CH46OC8YV4
Zinc J41CSQ7QDS
phthalocyanine V5PUF4VLGY

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7-16

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Rei Fujishiro (R)

Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan.

Hayato Sonoyama (H)

Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan.

Yuki Ide (Y)

Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan.

Takuya Fujimura (T)

Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan.

Ryo Sasai (R)

Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan. Electronic address: rsasai@riko.shimane-u.ac.jp.

Atsushi Nagai (A)

Department of Laboratory Medicine, Shimane University School of Medicine, Izumo, Japan.

Shigeki Mori (S)

Advanced Research Support Center, Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577, Japan.

Nichole E M Kaufman (NEM)

Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803-1804, USA.

Zehua Zhou (Z)

Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803-1804, USA.

M Graça H Vicente (MGH)

Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803-1804, USA.

Takahisa Ikeue (T)

Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan. Electronic address: ikeue@riko.shimane-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Synthesis, photodynamic activities, and...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Gallium › Synthesis, photodynamic activities, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis, photodynamic activities, and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Synthesis, photodynamic activities, and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Synthesis, photodynamic activities, and...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › Synthesis, photodynamic activities, and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › Synthesis, photodynamic activities, and...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Synthesis, photodynamic activities, and...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Zinc › Synthesis, photodynamic activities, and...