Staphylococcus aureus Decolonization of Mice With Monoclonal Antibody Neutralizing Protein A.
Animals
Antibodies, Monoclonal
/ immunology
Antibodies, Neutralizing
/ immunology
Female
Immunoglobulin A
/ metabolism
Immunoglobulin G
/ metabolism
Injections, Intraperitoneal
Mice, Inbred BALB C
Recombinant Proteins
/ administration & dosage
Staphylococcal Infections
/ drug therapy
Staphylococcal Protein A
/ administration & dosage
Staphylococcus aureus
/ immunology
Staphylococcus aureus
decolonization
monoclonal antibody
mouse model
staphylococcal protein A
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
23 02 2019
23 02 2019
Historique:
received:
22
07
2018
pubmed:
15
12
2018
medline:
9
1
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
Staphylococcus aureus persistently colonizes the nasopharynx of about one-third of the human population, a key risk factor for community- and hospital-acquired invasive infections. Current strategies for S. aureus decolonization include topical and systemic administration of antibiotics, which is associated with selection for antibiotic resistance and posttreatment recolonization. Using a mouse model for S. aureus colonization, we show here that systemic administration of a recombinant monoclonal antibody neutralizing staphylococcal protein A (SpA) can stimulate antibacterial immunoglobulin G and immunoglobulin A responses and promote S. aureus decolonization. These results suggest that antibody neutralizing SpA, a B-cell superantigen, may also be useful for S. aureus decolonization in humans.
Identifiants
pubmed: 30551184
pii: 5248354
doi: 10.1093/infdis/jiy597
pmc: PMC7184913
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Immunoglobulin A
0
Immunoglobulin G
0
Recombinant Proteins
0
Staphylococcal Protein A
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
884-888Subventions
Organisme : NIAID NIH HHS
ID : R01 AI052474
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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