Nanoencapsulation of the flavonoid dihydromyricetin protects against the genotoxicity and cytotoxicity induced by cationic nanocapsules.
Acrylic Resins
/ chemistry
Antioxidants
/ chemistry
Cations
Cell Line, Tumor
Cell Survival
Comet Assay
DNA Damage
Flavonoids
/ chemistry
Flavonols
/ chemistry
Humans
Leukocytes, Mononuclear
/ cytology
MCF-7 Cells
Nanocapsules
/ chemistry
Nanotechnology
Particle Size
Polymers
/ chemistry
Proteins
/ chemistry
Cytotoxicity
Eudragit RS100(®)
Genotoxicity
In vitro toxicity
Polymeric nanoparticles
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
26
07
2018
revised:
11
10
2018
accepted:
24
10
2018
entrez:
16
12
2018
pubmed:
16
12
2018
medline:
13
4
2019
Statut:
ppublish
Résumé
We evaluated the influence of nanoencapsulation of the flavonoid Dihydromyricetin (DMY) in reducing the genotoxicity and cytotoxicity induced by cationic nanocapsules. Assays were conducted in order to evaluate the potential of protein corona formation, cytotoxicity, genotoxicity and the antioxidant capacity. Nanocapsules containing DMY (NC-DMY) and free DMY (DMY-F) did not demonstrate cytotoxicity and genotoxicity. However, Eudragit RS100
Identifiants
pubmed: 30551295
pii: S0927-7765(18)30767-7
doi: 10.1016/j.colsurfb.2018.10.066
pii:
doi:
Substances chimiques
Acrylic Resins
0
Antioxidants
0
Cations
0
Flavonoids
0
Flavonols
0
Nanocapsules
0
Polymers
0
Proteins
0
Eudragit RS
33434-24-1
dihydromyricetin
KD8QND6427
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
798-805Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.