Therapeutic effect of ultrasound interventional perirenal catheter-assisted early peripancreatic lavage of protease inhibitor on severe acute pancreatitis in miniature pigs.
Enzyme inhibitor
Peripancreatic lavage
Severe acute pancreatitis
Ultrasonic intervention
Journal
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
ISSN: 1424-3911
Titre abrégé: Pancreatology
Pays: Switzerland
ID NLM: 100966936
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
31
08
2018
revised:
02
11
2018
accepted:
04
12
2018
pubmed:
16
12
2018
medline:
23
4
2019
entrez:
16
12
2018
Statut:
ppublish
Résumé
To study the therapeutic effect of early peripancreatic lavage of ulinastatin on severe acute pancreatitis(SAP). Sixteen pigs were divided into 4 groups: model(SAP), saline lavage(SL), ulinastatin lavage(UL), intravenous ulinastatin(IU). UL and SL group were given peripancreatic lavage of ulinastatin by ultrasound-guided perirenal catheterization and IU group was intravenously instilled with ulinastatin. The multi-organ functions and the inflammatory factors were observed. UL group has the best therapeutic effect. The changes of multi-organ functions and the inflammatory factors were compared with SAP group as follows. In time window of treatment: amylase (p < 0.01), lipase (p < 0.01), ALT (p > 0.05), AST (p < 0.05), CR (p < 0.01), UR (p < 0.01), IL-6 (p < 0.01), IL-10 (p < 0.01). In post-treatment phase: amylase (p < 0.01), lipase (p < 0.01), ALT (p < 0.01), AST (p < 0.01), CR (p < 0.05), UR (p > 0.05), IL-6 (p < 0.01), IL-10 (p < 0.01). Early peripancreatic lavage of ulinastatin in SAP could effectively improve the multi-organ functions and inflammatory response.
Identifiants
pubmed: 30551934
pii: S1424-3903(18)30763-4
doi: 10.1016/j.pan.2018.12.002
pii:
doi:
Substances chimiques
Glycoproteins
0
Protease Inhibitors
0
Tetracyclines
0
penimocycline
2176O1M292
Taurocholic Acid
5E090O0G3Z
Ampicillin
7C782967RD
urinastatin
OR3S9IF86U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
158-162Informations de copyright
Copyright © 2018 IAP and EPC. Published by Elsevier B.V. All rights reserved.