Engram Cell Excitability State Determines the Efficacy of Memory Retrieval.
Animals
Anisomycin
/ pharmacology
Bacterial Proteins
/ genetics
Channelrhodopsins
/ genetics
Conditioning, Psychological
/ physiology
Dentate Gyrus
/ cytology
Doxycycline
/ pharmacology
Freezing Reaction, Cataleptic
/ drug effects
Gene Expression Regulation
/ drug effects
Imidazoles
/ pharmacology
Luminescent Proteins
/ genetics
Membrane Potentials
/ drug effects
Mental Recall
/ drug effects
Mice
Mice, Transgenic
Microscopy, Confocal
Neurons
/ drug effects
Patch-Clamp Techniques
Phenanthrolines
/ pharmacology
Potassium Channels, Inwardly Rectifying
/ genetics
Protein Synthesis Inhibitors
/ pharmacology
Transduction, Genetic
engram
excitability
hippocampus
inward rectifier potassium channels
memory
memory access
memory retrieval
pattern completion
pattern separation
recognition
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
16 01 2019
16 01 2019
Historique:
received:
12
03
2018
revised:
12
10
2018
accepted:
15
11
2018
pubmed:
16
12
2018
medline:
14
8
2019
entrez:
16
12
2018
Statut:
ppublish
Résumé
Animals need to optimize the efficacy of memory retrieval to adapt to environmental circumstances for survival. The recent development of memory engram labeling technology allows a precise investigation of the processes associated with the recall of a specific memory. Here, we show that engram cell excitability is transiently increased following memory reactivation. This short-term increase of engram excitability enhances the subsequent retrieval of specific memory content in response to cues and is manifest in the animal's ability to recognize contexts more precisely and more effectively. These results reveal a hitherto unknown transient enhancement of context recognition based on the plasticity of engram cell excitability. They also suggest that recall of a contextual memory is influenced by previous but recent activation of the same engram. The state of excitability of engram cells mediates differential behavioral outcomes upon memory retrieval and may be crucial for survival by promoting adaptive behavior.
Identifiants
pubmed: 30551997
pii: S0896-6273(18)31038-9
doi: 10.1016/j.neuron.2018.11.029
pii:
doi:
Substances chimiques
2-(2-methyl-1H-indol-3-yl)-1H-imidazol(4,5-f)(1,10)phenanthroline
0
Bacterial Proteins
0
Channelrhodopsins
0
Imidazoles
0
Kir2.1 channel
0
Luminescent Proteins
0
Phenanthrolines
0
Potassium Channels, Inwardly Rectifying
0
Protein Synthesis Inhibitors
0
yellow fluorescent protein, Bacteria
0
Anisomycin
6C74YM2NGI
Doxycycline
N12000U13O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
274-284.e5Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.