Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes.


Journal

Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975

Informations de publication

Date de publication:
02 2019
Historique:
received: 16 06 2018
accepted: 29 10 2018
pubmed: 16 12 2018
medline: 25 7 2019
entrez: 16 12 2018
Statut: ppublish

Résumé

To assess the prevalence of cerebral small-vessel disease (SVD) in subjects with type 1 diabetes compared with healthy control subjects and to characterize the diabetes-related factors associated with SVD. This substudy was cross-sectional in design and included 191 participants with type 1 diabetes and median age 40.0 years (interquartile range 33.0-45.1) and 30 healthy age- and sex-matched control subjects. All participants underwent clinical investigation and brain MRIs, assessed for cerebral SVD. Cerebral SVD was more common in participants with type 1 diabetes than in healthy control subjects: any marker 35% vs. 10% ( Cerebral SVD, CMBs in particular, is more common in young people with type 1 diabetes compared with healthy control subjects.

Identifiants

pubmed: 30552131
pii: dc18-1302
doi: 10.2337/dc18-1302
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

327-330

Informations de copyright

© 2018 by the American Diabetes Association.

Auteurs

Lena M Thorn (LM)

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

Sara Shams (S)

Department of Radiology, Karolinska University Hospital, and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

Daniel Gordin (D)

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Joslin Diabetes Center, Harvard Medical School, Boston, MA.

Ron Liebkind (R)

Department of Neurology, Helsinki University Hospital, Helsinki, Finland.

Carol Forsblom (C)

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

Paula Summanen (P)

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.

Stefanie Hägg-Holmberg (S)

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

Turgut Tatlisumak (T)

Department of Neurology, Helsinki University Hospital, Helsinki, Finland.
Department of Clinical Neuroscience/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Oili Salonen (O)

Department of Radiology, Helsinki University Hospital, Helsinki, Finland.

Jukka Putaala (J)

Department of Neurology, Helsinki University Hospital, Helsinki, Finland.

Juha Martola (J)

Department of Radiology, Karolinska University Hospital, and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Department of Radiology, Helsinki University Hospital, Helsinki, Finland.

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