Sphingoid bases of dietary ceramide 2-aminoethylphosphonate, a marine sphingolipid, absorb into lymph in rats.
dietary sphingolipids
intestinal digestion
lymph cannulation
sphingolipid metabolism
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
04
04
2018
revised:
05
12
2018
pubmed:
16
12
2018
medline:
13
2
2020
entrez:
16
12
2018
Statut:
ppublish
Résumé
Various functions of dietary sphingolipids have been reported; however, little is known about marine sphingolipids. Ceramide 2-aminoethylphosphonate (CAEP), an abundant sphingolipid in marine mollusks, frequently has a unique triene type of sphingoid base [2-amino-9-methyl-4,8,10-octadecatriene-1,3-diol (d19:3)]. We previously reported that dietary CAEP prepared from the skin of squid was digested in the intestinal mucosa of mice via ceramides to yield free sphingoid bases. How dietary CAEP is then used in the body remains unclear. Here, we investigated the absorption of dietary CAEP using a lipid absorption assay on the lymph collected from rats with thoracic duct cannulation. Our results reveal that sphingoid bases derived from CAEP, including d16:1, d18:1, and d19:3, were detected in the lymph after administration of CAEP. Lymphatic recovery of d19:3 was lower than that of other sphingoid bases. A large fraction of the absorbed sphingoid bases was present as complex sphingolipids, whereas a smaller portion was present in the free form. Fatty acids in ceramide moieties found in the lymph were partially different from dietary CAEP, which indicates that sphingoid bases derived from CAEP could be, at least in part, resynthesized into complex sphingolipids. Future studies should elucidate the metabolism of sphingoid bases derived from CAEP.
Identifiants
pubmed: 30552287
pii: S0022-2275(20)32645-6
doi: 10.1194/jlr.M085654
pmc: PMC6358292
doi:
Substances chimiques
Ceramides
0
Dietary Carbohydrates
0
Sphingolipids
0
ceramide aminoethylphosphonate
0
Aminoethylphosphonic Acid
AH00YJQ334
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
333-340Informations de copyright
Copyright © 2019 Tomonaga et al.
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