Ultra-high field magnetic resonance imaging parameter mapping in the posterior horn of ex vivo human menisci.
MRI
Meniscus
OA
T2*
UTE
Journal
Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
29
06
2018
revised:
26
11
2018
accepted:
03
12
2018
pubmed:
16
12
2018
medline:
4
6
2020
entrez:
16
12
2018
Statut:
ppublish
Résumé
To investigate the relationship between meniscus magnetic resonance (MR) relaxation parameters and meniscus degradation through quantitative imaging of ex vivo posterior horns of menisci from subjects with and without knee osteoarthritis (OA). We sampled medial and lateral menisci from ten medial compartment knee OA patients (mean age 63 years) undergoing total knee replacement and from ten deceased donors (references, mean age 51 years). MR relaxation parameters T2*, T2 and T1 of the posterior horn were measured at a 9.4 T scanner. Comparisons were made between OA patients and references (with adjustment for age) as well as between medial and lateral menisci from the same knees. Mean values (standard deviation) of mean T2* were 13 (3.8), 6.9 (2.3), 7.2 (1.9) and 7.2 (1.7) ms for the medial and lateral patient menisci and the medial and lateral reference menisci, respectively. Corresponding values were 17 (3.7), 9.0 (2.2), 12 (4) and 9.0 (1.3) ms for T2 and 1810 (150), 1630 (30), 1580 (90) and 1560 (50) ms for T1. All three relaxation times were significantly longer in medial OA menisci compared to the other groups. Among medial reference menisci, relaxation times (mainly T1) tended to increase with age. MR relaxation times T2*, T2 and T1 in the posterior horn are longer in the medial menisci of patients with end-stage medial compartment knee OA compared to the corresponding lateral menisci and to reference menisci. The meniscus seems to undergo intrasubstance alterations related to both OA and ageing.
Identifiants
pubmed: 30552967
pii: S1063-4584(18)31556-5
doi: 10.1016/j.joca.2018.12.003
pmc: PMC7610687
mid: EMS122044
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
476-483Subventions
Organisme : European Research Council
ID : 771121
Pays : International
Informations de copyright
Copyright © 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Références
Ann Transplant. 1997;2(1):52-4
pubmed: 9869843
Magn Reson Med. 2004 Mar;51(3):503-9
pubmed: 15004791
Osteoarthritis Cartilage. 2009 Aug;17(8):988-94
pubmed: 19332176
Magn Reson Med. 2014 Mar;71(3):1015-23
pubmed: 23606167
Knee Surg Sports Traumatol Arthrosc. 2008 Apr;16(4):353-9
pubmed: 18066525
Osteoarthritis Cartilage. 2013 Jun;21(6):796-805
pubmed: 23499673
Skeletal Radiol. 2016 Dec;45(12):1649-1660
pubmed: 27639388
BMC Musculoskelet Disord. 2017 May 18;18(1):202
pubmed: 28521823
Arthritis Rheum. 2009 Mar;60(3):831-9
pubmed: 19248082
Radiology. 2016 Jul;280(1):161-8
pubmed: 26829523
N Engl J Med. 2008 Sep 11;359(11):1108-15
pubmed: 18784100
Osteoarthritis Cartilage. 2012 Jun;20(6):486-94
pubmed: 22306000
Am J Sports Med. 2014 Aug;42(8):1847-56
pubmed: 24812196
Radiology. 2005 Jan;234(1):162-70
pubmed: 15564387
J Magn Reson Imaging. 2009 Feb;29(2):412-21
pubmed: 19161197
Radiology. 2016 Jan;278(1):164-71
pubmed: 26172533
Ann Rheum Dis. 2011 Jan;70(1):74-9
pubmed: 20705634
PLoS One. 2013;8(3):e59769
pubmed: 23555775
Clin Sports Med. 1990 Jul;9(3):539-49
pubmed: 2379242
Ann Rheum Dis. 1984 Aug;43(4):635-40
pubmed: 6548109
Osteoarthritis Cartilage. 2007 Feb;15(2):198-204
pubmed: 16949313
J Bone Joint Surg Br. 1961 Nov;43-B:752-7
pubmed: 14038135