Spectral analysis of peri-pharyngeal muscles' EMG in patients with OSA and healthy subjects.
Centroid frequency
Genioglossus
Obstructive sleep apnea
Spectral analysis
Upper airway
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
01
10
2018
revised:
09
11
2018
accepted:
13
12
2018
pubmed:
17
12
2018
medline:
4
4
2019
entrez:
17
12
2018
Statut:
ppublish
Résumé
In addition to dyscoordination of upper airway dilator muscles activity, sleep may also alter the pattern of intra-muscular activation of single motor units (SMUs). Such changes should be identifiable by a state dependent change in EMG power spectrum, i.e., a shift in centroid frequency (ƒc) during sleep. EMGs of the genioglossus and four other peri-pharyngeal muscles were recorded in OSA patients (n = 8), age-matched healthy subjects (n = 7), and 5 young healthy subjects, and ƒc was calculated for wakefulness and sleep periods. ƒc decreased with the onset of sleep and returned to baseline levels after arousal. ƒc of all muscles decreased similarly and significantly during sleep in the OSA and the age-matched healthy subjects, but not in the young subjects. The pattern of decrease in ƒc is compatible with altered synchronization of SMUs during sleep. We speculate that these changes may contribute to the failure of dilator muscles to improve flow limitation during sleep in older subjects.
Identifiants
pubmed: 30553943
pii: S1569-9048(18)30310-0
doi: 10.1016/j.resp.2018.12.002
pmc: PMC7422933
mid: NIHMS1589855
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
53-57Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL144859
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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