Photo-triggered polymer nanomedicines: From molecular mechanisms to therapeutic applications.
Drug-delivery
Gels
Light- responsive
Nanomedicine
Nanoparticles
Polymers
Journal
Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
28
06
2018
revised:
28
10
2018
accepted:
11
12
2018
pubmed:
17
12
2018
medline:
25
2
2020
entrez:
17
12
2018
Statut:
ppublish
Résumé
The use of nanotechnology to improve treatment efficacy and reduce side effects is central to nanomedicine. In this context, stimuli-responsive drug delivery systems (DDS) such as chemical/physical gels or nanoparticles such as polymersomes, micelles or nanogels are particularly promising and are the focus of this review. Several stimuli have been considered but light as an exogenous trigger presents many advantages that are pertinent for clinical applications such as high spatial and temporal control and low cost. Underlying mechanisms required for the release of therapeutic agents in vitro and in vivo range from the molecular scale, namely photoisomerization, hydrophobicity photoswitching, photocleavage or heat generation via nanoheaters, through to the macromolecular scale. As well as these approaches, DDS destabilization, DDS permeation pore unblocking and formation are discussed.
Identifiants
pubmed: 30553952
pii: S0169-409X(18)30314-4
doi: 10.1016/j.addr.2018.12.010
pii:
doi:
Substances chimiques
Polymers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
148-166Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.