Efficacy of calcium excretion and calcium/creatinine clearance ratio in the differential diagnosis of familial hypocalciuric hypercalcemia and primary hyperparathyroidism.
Adult
Aged
Calcium
/ urine
Cohort Studies
Creatinine
/ urine
Diagnosis, Differential
Female
Follow-Up Studies
Humans
Hypercalcemia
/ blood
Hyperparathyroidism, Primary
/ blood
Male
Middle Aged
Parathyroid Hormone
/ blood
Parathyroidectomy
/ methods
Prospective Studies
Risk Assessment
Treatment Outcome
calcium excretion
calcium/creatinine clearance ratio
familial hypocalciuric hypercalcemia
parathyroid surgery
primary hyperparathyroidism
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
25
04
2018
revised:
08
08
2018
accepted:
21
11
2018
pubmed:
17
12
2018
medline:
24
11
2020
entrez:
17
12
2018
Statut:
ppublish
Résumé
Twenty-four-hour renal calcium-excretion (CE) and calcium/creatinine-clearance-ratio (CCCR), respectively, are widely used to rule out familial hypocalciuric hypercalcemia (FHH) in patients with suspected primary hyperparathyroidism before surgery. The aim was to evaluate the practicability of CE compared to CCCR. We analyzed biochemical parameters, surgical treatment, gene mutation results, and long-term follow-up data of 198 patients (including 14 patients with FHH) and the discriminative power of CE and CCCR. Twenty four patients (12.1%) had a low CE and 35 patients (20.2%) had a CCCR indicating FHH. However, eight patients with FHH (57.1%) had a normal or increased CE. Correspondingly, only eight cases of FHH (57.1%) were correctly predicted by CCCR. Sensitivity/specificity were 42.9%/89.9% for CE and 64.3%/79.9% for CCCR, showing no statistical differences (P = 0.482) between both methods. Neither CE nor CCCR was able to distinguish between PHPT and FHH but may help to narrow down potential FHH patients.
Sections du résumé
BACKGROUND
Twenty-four-hour renal calcium-excretion (CE) and calcium/creatinine-clearance-ratio (CCCR), respectively, are widely used to rule out familial hypocalciuric hypercalcemia (FHH) in patients with suspected primary hyperparathyroidism before surgery. The aim was to evaluate the practicability of CE compared to CCCR.
PATIENTS AND METHODS
We analyzed biochemical parameters, surgical treatment, gene mutation results, and long-term follow-up data of 198 patients (including 14 patients with FHH) and the discriminative power of CE and CCCR.
RESULTS
Twenty four patients (12.1%) had a low CE and 35 patients (20.2%) had a CCCR indicating FHH. However, eight patients with FHH (57.1%) had a normal or increased CE. Correspondingly, only eight cases of FHH (57.1%) were correctly predicted by CCCR. Sensitivity/specificity were 42.9%/89.9% for CE and 64.3%/79.9% for CCCR, showing no statistical differences (P = 0.482) between both methods.
CONCLUSION
Neither CE nor CCCR was able to distinguish between PHPT and FHH but may help to narrow down potential FHH patients.
Substances chimiques
Parathyroid Hormone
0
Creatinine
AYI8EX34EU
Calcium
SY7Q814VUP
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1372-1378Informations de copyright
© 2018 Wiley Periodicals, Inc.