Electroconvulsive therapy induced gray matter increase is not necessarily correlated with clinical data in depressed patients.

Adult Brain / diagnostic imaging Brain Mapping Depressive Disorder, Major / physiopathology Electroconvulsive Therapy / adverse effects Female Gray Matter / diagnostic imaging Humans Magnetic Resonance Imaging Male Middle Aged Neuronal Plasticity
Amygdala Depression Electroconvulsive therapy Gray matter Hippocampus

Journal

Brain stimulation
ISSN: 1876-4754
Titre abrégé: Brain Stimul
Pays: United States
ID NLM: 101465726

Informations de publication

Date de publication:
Historique:
received: 12 06 2018
revised: 08 11 2018
accepted: 29 11 2018
pubmed: 18 12 2018
medline: 25 6 2019
entrez: 18 12 2018
Statut: ppublish

Résumé

Electroconvulsive therapy (ECT) and depression have been associated with brain volume changes, especially in the hippocampus and the amygdala. In this retrospective study we collected data from individual pre-post ECT whole brain magnetic resonance imaging scans of depressed patients from six German university hospitals. Gray matter volume (GMV) changes were quantified via voxel-based morphometry in a total sample of 92 patients with major depressive episodes (MDE). Additionally, 43 healthy controls were scanned twice within a similar time interval. Most prominently longitudinal GMV increases occurred in temporal lobe regions. Within specific region of interests we detected significant increases of GMV in the hippocampus and the amygdala. These results were more pronounced in the right hemisphere. Decreases in GMV were not observed. GMV changes did not correlate with psychopathology, age, gender or number of ECT sessions. We ruled out white matter reductions as a possible indirect cause of the detected GMV increase. The present findings support the notion of hippocampus and amygdala modulation following an acute ECT series in patients with MDE. These results corroborate the hypothesis that ECT enables primarily unspecific and regionally dependent neuroplasticity effects to the brain.

Sections du résumé

BACKGROUND
Electroconvulsive therapy (ECT) and depression have been associated with brain volume changes, especially in the hippocampus and the amygdala.
METHODS
In this retrospective study we collected data from individual pre-post ECT whole brain magnetic resonance imaging scans of depressed patients from six German university hospitals. Gray matter volume (GMV) changes were quantified via voxel-based morphometry in a total sample of 92 patients with major depressive episodes (MDE). Additionally, 43 healthy controls were scanned twice within a similar time interval.
RESULTS
Most prominently longitudinal GMV increases occurred in temporal lobe regions. Within specific region of interests we detected significant increases of GMV in the hippocampus and the amygdala. These results were more pronounced in the right hemisphere. Decreases in GMV were not observed. GMV changes did not correlate with psychopathology, age, gender or number of ECT sessions. We ruled out white matter reductions as a possible indirect cause of the detected GMV increase.
CONCLUSION
The present findings support the notion of hippocampus and amygdala modulation following an acute ECT series in patients with MDE. These results corroborate the hypothesis that ECT enables primarily unspecific and regionally dependent neuroplasticity effects to the brain.

Identifiants

DOI: 10.1016/j.brs.2018.11.017 PMID: 30554869
pubmed: 30554869
pii: S1935-861X(18)30418-2
doi: 10.1016/j.brs.2018.11.017
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

335-343

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Alexander Sartorius (A)

Research Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany. Electronic address: alexander.sartorius@zi-mannheim.de.

Traute Demirakca (T)

Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Andreas Böhringer (A)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Christian Clemm von Hohenberg (C)

Research Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Suna Su Aksay (SS)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Jan Malte Bumb (JM)

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.

Laura Kranaster (L)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Thomas Nickl-Jockschat (T)

Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; Department of Psychiatry, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Michael Grözinger (M)

Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany.

Philipp A Thomann (PA)

Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Germany; Center for Mental Health, Odenwald District Healthcare Center, Uniklinik RWTH, Aachen, Germany.

Robert Christian Wolf (RC)

Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Germany.

Peter Zwanzger (P)

kbo-Inn-Salzach-Hospital, Gabersee 7, 83512, Wasserburg am Inn, Germany; Department of Psychiatry and Psychotherapy, Albert-Schweitzer-Campus 1, University of Muenster, Germany; Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Germany.

Udo Dannlowski (U)

Department of Psychiatry and Psychotherapy, Albert-Schweitzer-Campus 1, University of Muenster, Germany.

Ronny Redlich (R)

Department of Psychiatry and Psychotherapy, Albert-Schweitzer-Campus 1, University of Muenster, Germany.

Maxim Zavorotnyy (M)

Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Marburg Center for Mind, Brain and Behavior - MCMBB, University of Marburg, Germany.

Rebecca Zöllner (R)

Department of Psychiatry and Psychotherapy, University of Marburg, Germany.

Isabel Methfessel (I)

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.

Matthias Besse (M)

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.

David Zilles (D)

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.

Gabriele Ende (G)

Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Electroconvulsive therapy induced gray matter...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Electroconvulsive therapy induced gray matter...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Electroconvulsive therapy induced gray matter...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Electroconvulsive therapy induced gray matter...
questionsmedicales.fr › Disciplines et activités comportementales › Techniques psychologiques › Électrochoc › Électroconvulsivothérapie › Electroconvulsive therapy induced gray matter...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › Electroconvulsive therapy induced gray matter...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Electroconvulsive therapy induced gray matter...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Electroconvulsive therapy induced gray matter...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Electroconvulsive therapy induced gray matter...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Electroconvulsive therapy induced gray matter...