Effect of a high-fat diet on the rat bladder wall and bioactive action of Brazil nut oil.
Bladder
Diet, High-Fat
Nuts
Rats
Journal
International braz j urol : official journal of the Brazilian Society of Urology
ISSN: 1677-6119
Titre abrégé: Int Braz J Urol
Pays: Brazil
ID NLM: 101158091
Informations de publication
Date de publication:
Historique:
received:
07
08
2018
accepted:
05
10
2018
pubmed:
18
12
2018
medline:
25
6
2019
entrez:
18
12
2018
Statut:
ppublish
Résumé
High-fat diet-induced obesity is associated with metabolic disorders. The Brazil nut has bioactive substances and has been used to control the damage caused by obesity in several organs. The work intended to show the damage caused by high-fat diet in the bladder wall and if the Brazil nut oil added to the diet could ameliorate or reverse this effect. Sixty-day-old rats were divided into two groups: C (control, n = 30) and HF (high-fat, n = 30) diets. At 90 days, 10 animals of each group were sacrificed. The others were divided into 4 groups: C and HF (animals that maintained their previous diet, n = 10 for each group) and C / Bno and HF / Bno (animals whose control or high-fat diet was supplemented by Brazil nut oil, n = 10 for each group). Sacrifice occurred at 120 days, and the bladders were removed and analyzed. Epithelial height was increased in the HF compared to the C group. In contrast, the C / Bno had a lower epithelial height compared to the others. The percentage of collagen between the detrusor muscle fibers was significantly greater in C / Bno, HF and HF / Bno than in control group. The HF had a larger muscle fiber diameter than the C group, while the C / Bno presented lower values than the HF and HF / Bno groups. HF diets induced bladder wall damage. These changes in the rat's bladder wall were partially reversed by the Bno.
Identifiants
pubmed: 30556993
doi: 10.1590/S1677-5538.IBJU.2018.0547
pii: IBJU20180547
pmc: PMC6442138
doi:
Substances chimiques
Plant Oils
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-168Informations de copyright
Copyright® by the International Brazilian Journal of Urology.
Déclaration de conflit d'intérêts
Conflict of interest: None declared.
Références
Circulation. 2004 Apr 6;109(13):1609-14
pubmed: 15037535
J Clin Endocrinol Metab. 2004 Jun;89(6):2522-5
pubmed: 15181019
Age Ageing. 2006 Jan;35(1):16-24
pubmed: 16234314
Endocrine. 2008 Apr;33(2):176-88
pubmed: 18483882
Am J Clin Nutr. 2009 May;89(5):1649S-56S
pubmed: 19321561
Int J Biochem Cell Biol. 2010 Feb;42(2):306-17
pubmed: 19931412
Nutr Metab (Lond). 2011 May 28;8(1):32
pubmed: 21619692
Urology. 2012 Feb;79(2):266-9
pubmed: 22130358
Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1363-9
pubmed: 22993071
Cell Physiol Biochem. 2012;30(5):1169-80
pubmed: 23171868
Br J Biomed Sci. 2013;70(1):1-5
pubmed: 23617090
PLoS One. 2013 Jun 24;8(6):e66636
pubmed: 23826106
PLoS One. 2014 Jul 16;9(7):e102876
pubmed: 25029463
Acta Cir Bras. 2014;29 Suppl 1:39-44
pubmed: 25185055
Curr Opin Endocrinol Diabetes Obes. 2015 Aug;22(4):277-82
pubmed: 26087341
Int Braz J Urol. 2015 May-Jun;41(3):569-75
pubmed: 26200553
Biomed Res Int. 2015;2015:832156
pubmed: 26413547
Low Urin Tract Symptoms. 2013 May;5(2):101-8
pubmed: 26663378
J Biomech. 1989;22(5):419-26
pubmed: 2777816
Int Braz J Urol. 2018 Mar-Apr;44(2):384-389
pubmed: 29039895
Prostate. 2018 Mar;78(4):289-293
pubmed: 29315701
Am J Reprod Immunol. 2018 Sep;80(3):e12868
pubmed: 29736947
J Nutr. 1993 Nov;123(11):1939-51
pubmed: 8229312