The m
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
pubmed:
18
12
2018
medline:
1
10
2019
entrez:
18
12
2018
Statut:
ppublish
Résumé
The central dogma of molecular biology introduced by Crick describes a linear flow of information from DNA to mRNA to protein. Since then it has become evident that RNA undergoes several maturation steps such as capping, splicing, 3'-end processing, and editing. Likewise, nucleotide modifications are common in mRNA and are present in all organisms impacting on the regulation of gene expression. The most abundant modification found in mRNA is N6-methyladenosine (m
Identifiants
pubmed: 30557013
doi: 10.1021/acs.biochem.8b01166
doi:
Substances chimiques
RNA, Messenger
0
N-methyladenosine
CLE6G00625
METTL14 protein, human
EC 2.1.1.-
Methyltransferases
EC 2.1.1.-
METTL3 protein, human
EC 2.1.1.62
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-378Subventions
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom