Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.

Biomarkers, Tumor / genetics Carcinoma, Ovarian Epithelial / genetics Cohort Studies DNA Methylation Female Genetic Predisposition to Disease Humans Models, Genetic Ovarian Neoplasms / genetics Predictive Value of Tests Risk White People / genetics Women's Health

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
01 02 2019
Historique:
received: 30 08 2018
revised: 16 10 2018
accepted: 06 12 2018
pubmed: 19 12 2018
medline: 22 11 2019
entrez: 19 12 2018
Statut: ppublish

Résumé

DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (

Identifiants

DOI: 10.1158/0008-5472.CAN-18-2726 PMID: 30559148 PMC: PMC6359948
pubmed: 30559148
pii: 0008-5472.CAN-18-2726
doi: 10.1158/0008-5472.CAN-18-2726
pmc: PMC6359948
mid: NIHMS1516594
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

505-517

Subventions

Organisme : NCI NIH HHS
ID : U01 CA069417
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA080668
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
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Organisme : NCI NIH HHS
ID : P30 CA076292
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Organisme : NCI NIH HHS
ID : U19 CA148112
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 10124
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : Cancer Research UK
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Organisme : NCI NIH HHS
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Informations de copyright

©2018 American Association for Cancer Research.

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Auteurs

Yaohua Yang (Y)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Lang Wu (L)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Xiang Shu (X)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
ORCID: 0000-0002-4129-9403

Yingchang Lu (Y)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
ORCID: 0000-0002-4129-9403

Qiuyin Cai (Q)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Alicia Beeghly-Fadiel (A)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Bingshan Li (B)

Department of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee.

Fei Ye (F)

Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.

Andrew Berchuck (A)

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.

Hoda Anton-Culver (H)

Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, California.

Susana Banerjee (S)

Gynaecology Unit, Royal Marsden Hospital, London, United Kingdom.

Javier Benitez (J)

Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.

Line Bjørge (L)

Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Center for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.

James D Brenton (JD)

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
ORCID: 0000-0002-5738-6683

Ralf Butzow (R)

Department of Pathology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Ian G Campbell (IG)

Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-8919-1971

Kexin Chen (K)

Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Linda S Cook (LS)

University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico.
Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada.

Daniel W Cramer (DW)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Anna deFazio (A)

Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
ORCID: 0000-0003-0057-4744

Joe Dennis (J)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
ORCID: 0000-0003-4591-1214

Jennifer A Doherty (JA)

Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.

Thilo Dörk (T)

Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

Diana M Eccles (DM)

Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

Digna Velez Edwards (DV)

Vanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee.

Peter A Fasching (PA)

David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California.
Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
ORCID: 0000-0003-4885-8471

Renée T Fortner (RT)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-1426-8505

Simon A Gayther (SA)

The Center for Bioinformatics and Functional Genomics at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Graham G Giles (GG)

Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
ORCID: 0000-0003-4946-9099

Rosalind M Glasspool (RM)

The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.

Ellen L Goode (EL)

Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.

Marc T Goodman (MT)

Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California.

Jacek Gronwald (J)

Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

Holly R Harris (HR)

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Department of Epidemiology, University of Washington, Seattle, Washington.
ORCID: 0000-0002-2572-6727

Florian Heitz (F)

Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany.

Michelle A Hildebrandt (MA)

Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Estrid Høgdall (E)

Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

Claus K Høgdall (CK)

The Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

David G Huntsman (DG)

Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.
OVCARE, Vancouver Coastal Health Research Centre, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

Siddhartha P Kar (SP)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

Beth Y Karlan (BY)

Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Linda E Kelemen (LE)

Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.

Lambertus A Kiemeney (LA)

Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
ORCID: 0000-0002-2368-1326

Susanne K Kjaer (SK)

Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-8347-1398

Anita Koushik (A)

CHUM Research Centre (CRCHUM) and Département de Médicine Sociale et Préventive, Université de Montréal, Montréal, Quebec, Canada.
ORCID: 0000-0001-5304-7660

Diether Lambrechts (D)

VIB Center for Cancer Biology, VIB and Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.

Nhu D Le (ND)

Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.

Douglas A Levine (DA)

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Gynecologic Oncology, Laura and Isaac Pearlmutter Cancer Center, NYU Langone Medical Center, New York, New York.

Leon F Massuger (LF)

Department of Gynaecology, Radboud Institute for Molecular Life sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Keitaro Matsuo (K)

Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Taymaa May (T)

Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada.

Iain A McNeish (IA)

Department Surgery & Cancer, Imperial College London, London, United Kingdom.
Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, United Kingdom.
ORCID: 0000-0002-9387-7586

Usha Menon (U)

MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, United Kingdom.
ORCID: 0000-0003-3708-1732

Francesmary Modugno (F)

Womens Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Alvaro N Monteiro (AN)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
ORCID: 0000-0002-8448-4801

Patricia G Moorman (PG)

Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.

Kirsten B Moysich (KB)

Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.

Roberta B Ness (RB)

School of Public Health, University of Texas Health Science Center at Houston (UTHealth), Houston, Texas.

Heli Nevanlinna (H)

Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-0916-2976

Håkan Olsson (H)

Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.

N Charlotte Onland-Moret (NC)

Julius Center for Health Sciences and Primary Care, University Utrecht, UMC Utrecht, Utrecht, the Netherlands.

Sue K Park (SK)

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Cancer Research Institute, Seoul National University, Seoul, Korea.
ORCID: 0000-0001-5002-9707

James Paul (J)

The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
ORCID: 0000-0001-7367-5816

Celeste L Pearce (CL)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.

Tanja Pejovic (T)

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.
Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.

Catherine M Phelan (CM)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.

Malcolm C Pike (MC)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.

Susan J Ramus (SJ)

School of Women's and Children's Health, Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia.
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
ORCID: 0000-0003-0005-7798

Elio Riboli (E)

Imperial College London, London, United Kingdom.

Cristina Rodriguez-Antona (C)

Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
ORCID: 0000-0001-8750-7338

Isabelle Romieu (I)

Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France.

Dale P Sandler (DP)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina.
ORCID: 0000-0002-6776-0018

Joellen M Schildkraut (JM)

Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.

Veronica W Setiawan (VW)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Kang Shan (K)

Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.

Nadeem Siddiqui (N)

Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom.

Weiva Sieh (W)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Department of Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.

Meir J Stampfer (MJ)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Rebecca Sutphen (R)

Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida.

Anthony J Swerdlow (AJ)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom.

Lukasz M Szafron (LM)

Department of Immunology, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.
ORCID: 0000-0003-1670-0274

Soo Hwang Teo (SH)

Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
ORCID: 0000-0002-0444-590X

Shelley S Tworoger (SS)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Research Institute and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
ORCID: 0000-0002-6986-7046

Jonathan P Tyrer (JP)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.

Penelope M Webb (PM)

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0003-0733-5930

Nicolas Wentzensen (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Emily White (E)

Fred Hutchinson Cancer Research Center, Seattle, Washington.
Department of Epidemiology, University of Washington, Seattle, Washington.

Walter C Willett (WC)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0001-7387-6845

Yin Ling Woo (YL)

Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.

Anna H Wu (AH)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Li Yan (L)

Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.

Drakoulis Yannoukakos (D)

Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Athens, Greece.

Georgia Chenevix-Trench (G)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Thomas A Sellers (TA)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.

Paul D P Pharoah (PDP)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Jirong Long (J)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee. jirong.long@vumc.org.

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questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Genetic Data from Nearly 63,000 Women of...
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