Biomarker-Measured Unhealthy Alcohol Use in Relation to CD4 Count Among Individuals Starting ART in Sub-Saharan Africa.
Alcohol use
Biomarker
HIV treatment
Sub-Saharan Africa
Journal
AIDS and behavior
ISSN: 1573-3254
Titre abrégé: AIDS Behav
Pays: United States
ID NLM: 9712133
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
pubmed:
19
12
2018
medline:
23
8
2019
entrez:
19
12
2018
Statut:
ppublish
Résumé
Individuals are initiating antiretroviral therapy (ART) at earlier HIV disease stages. Unhealthy alcohol use is a known barrier to successful HIV treatment outcomes, yet it is unclear whether the problem varies by disease stage. We measured alcohol use with an objective biomarker (phosphatidylethanol [PEth]), comparing individuals (n = 401) with early (CD4 > 350 cells/mL, WHO Stage 1) versus late (CD4 < 200 cells/mL) ART initiation in HIV care in Uganda and South Africa (SA). We examined the association between CD4 count and biomarker results using multivariable regression modeling, and compared PEth results to self-report to assess underreporting. Overall, 32.2% (n = 129) had unhealthy alcohol use (PEth ≥ 50 ng/ml). Early ART initiation was significantly associated with unhealthy alcohol use in Uganda (AOR 2.65; 95% CI: 1.05-6.72), but not SA (AOR 1.00; 95% CI: 0.46-2.17). In Uganda, 23.2% underreported unhealthy alcohol use versus 11.6% in SA (χ
Identifiants
pubmed: 30560484
doi: 10.1007/s10461-018-2364-2
pii: 10.1007/s10461-018-2364-2
pmc: PMC6535416
mid: NIHMS1015290
doi:
Substances chimiques
Anti-HIV Agents
0
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Pagination
1656-1667Subventions
Organisme : NIAID NIH HHS
ID : R38 AI140299
Pays : United States
Organisme : NIDA NIH HHS
ID : K23 DA041901
Pays : United States
Organisme : NIDA NIH HHS
ID : K23DA041901
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24 AA022586
Pays : United States
Organisme : Bill and Melinda Gates Foundation
ID : OPP1056051
Organisme : NIAID NIH HHS
ID : U01 AI103408
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24AA022586
Pays : United States
Investigateurs
Jessica Haberer
(J)
Catherine Orrell
(C)
Norma Ware
(N)
Mwebesa Bosco Bwana
(MB)
Asiimwe Stephen
(A)
Amanyire Gideon
(A)
Tumwesigye Elioda
(T)
David Bangsberg
(D)
Alex Tsai
(A)
Mark Siedner
(M)
Lynn Matthews
(L)
Ingrid Katz
(I)
Monique Wyatt
(M)
Nomakhaya April
(N)
Alienah Mpahleni
(A)
Vivie Situlo
(V)
Speech Mzamo
(S)
Nomsa Ngwenya
(N)
Khosi Tshangela Regina Panda
(KTR)
Teboho Linda
(T)
Christine Atwiine
(C)
Sheila Moonight
(S)
Edna Tindimwebwa
(E)
Nicholas Mugisha
(N)
Peace Atwogeire
(P)
Vian Namana
(V)
Catherine Kyampaire
(C)
Gabriel Nuwagaba
(G)
Annet Kembabazi
(A)
Stephen Mugisha
(S)
Victoria Nanfuka
(V)
Anna Cross
(A)
Nicky Kelly
(N)
Daphne Moralie
(D)
Kate Bell
(K)
Nicholas Musinguzi
(N)
Dolphina Cogill
(D)
Justus Ashaba
(J)
Zoleka Xapa
(Z)
Mathias Orimwesiga
(M)
Elly Tuhanamagyezi
(E)
Catherine Kyampaire
(C)
Don Bosco Mpanga
(DB)
Leonia Kyarisima
(L)
Simone Kigozi
(S)
Edgar October
(E)
Silver Mugisha
(S)
Ibrahim Kiviiri
(I)
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