The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study.
Adult
Body Mass Index
Body Weight
/ genetics
Cohort Studies
DNA Methylation
/ genetics
Female
Genome-Wide Association Study
/ methods
Humans
Longitudinal Studies
Male
Mendelian Randomization Analysis
/ methods
Middle Aged
Nicotine
/ genetics
Polymorphism, Single Nucleotide
/ genetics
Risk Factors
Smoking
/ genetics
Smoking Cessation
Journal
Human molecular genetics
ISSN: 1460-2083
Titre abrégé: Hum Mol Genet
Pays: England
ID NLM: 9208958
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
11
05
2018
revised:
21
11
2018
accepted:
30
11
2018
pubmed:
19
12
2018
medline:
2
7
2019
entrez:
19
12
2018
Statut:
ppublish
Résumé
Given clear evidence that smoking lowers weight, it is possible that individuals with higher body mass index (BMI) smoke in order to lose or maintain their weight. We performed Mendelian randomization (MR) analyses of the effects of BMI on smoking behaviour in UK Biobank and the Tobacco and Genetics Consortium genome-wide association study (GWAS), on cotinine levels and nicotine metabolite ratio (NMR) in published GWAS and on DNA methylation in the Avon Longitudinal Study of Parents and Children. Our results indicate that higher BMI causally influences lifetime smoking, smoking initiation, smoking heaviness and also DNA methylation at the aryl-hydrocarbon receptor repressor (AHRR) locus, but we do not see evidence for an effect on smoking cessation. While there is no strong evidence that BMI causally influences cotinine levels, suggestive evidence for a negative causal influence on NMR may explain this. There is a causal effect of BMI on smoking, but the relationship is likely to be complex due to opposing effects on behaviour and metabolism.
Identifiants
pubmed: 30561638
pii: 5251961
doi: 10.1093/hmg/ddy434
pmc: PMC6452214
doi:
Substances chimiques
Nicotine
6M3C89ZY6R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1322-1330Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/6
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C57854/A22171
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 22171
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 19169
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C18281/A19169
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/7
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K023195/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press.
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