Aging-Related Expression of Twinfilin-1 Regulates Cholangiocyte Biological Response to Injury.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
10
07
2018
accepted:
08
12
2018
pubmed:
19
12
2018
medline:
4
7
2020
entrez:
19
12
2018
Statut:
ppublish
Résumé
Disorders of the biliary tree develop and progress differently according to patient age. It is currently not known whether the aging process affects the response to injury of cholangiocytes. The aim of this study was to identify molecular pathways associated with cholangiocyte aging and to determine their effects in the biological response to injury of biliary cells. A panel of microRNAs (miRs) involved in aging processes was evaluated in cholangiocytes of young and old mice (2 months and 22 months of age, respectively) and subjected to a model of sclerosing cholangitis. Intracellular pathways that are common to elevated miRs were identified by in silico analysis. Cell proliferation and senescence were evaluated in Twinfilin-1 (Twf1) knocked-down cells. In vivo, senescence-accelerated prone mice (Samp8, a model for accelerated aging), Twf1
Substances chimiques
MicroRNAs
0
Microfilament Proteins
0
Twf1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
883-898Subventions
Organisme : Università Politecnica delle Marche
ID : 040020_R.SCIENT.A_2018
Pays : International
Organisme : Spanish Ministry of Economy and Competitiveness
ID : FIS PI12/00380
Pays : International
Organisme : Spanish Ministry of Economy and Competitiveness
ID : FIS PI15/01132
Pays : International
Organisme : Miguel Servet Programme
ID : CON14/00129
Pays : International
Organisme : Fondo Europeo de Desarrollo Regional
Pays : International
Organisme : Basque Foundation for Innovation and Health Research
ID : BIO15/CA/016/BD
Pays : International
Organisme : Fundación Científica de la Asociación Española Contra el Cáncer
Pays : International
Organisme : Basque Government
ID : PRE_2016_1_0152
Pays : International
Organisme : Norwegian PSC Research Center, Southeastern Norwegian Health Authorities and Research Council of Norway
Pays : International
Informations de copyright
© 2018 by the American Association for the Study of Liver Diseases.
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