Endometriosis and cancer.
Atypical endometriosis
Clear cell carcinoma
Endometriosis
Genetic alterations
Ovarian carcinoma
Oxidative stress
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
12
12
2018
revised:
13
12
2018
accepted:
14
12
2018
pubmed:
19
12
2018
medline:
15
2
2020
entrez:
19
12
2018
Statut:
ppublish
Résumé
Endometriosis, characterized by the presence of extra-uterine endometrium, is a common gynecologic disorder in reproductive-age women. Although the detailed molecular mechanism of etiology remains unelucidated, recent studies have gradually revealed both genetic and epigenetic backgrounds of the development of endometriosis. In clinical practice, endometriosis has been recognized as a precursor lesion of several types of malignancies and endometriosis-associated carcinoma. An imbalance between reactive oxygen species and local antioxidants has been reported to contribute to the development of endometriosis-associated carcinoma as well as the pathophysiology of this disease through a systemic inflammatory response in the peritoneal cavity. This review mainly presents an epidemiology, possible etiology of endometriosis, precursor lesions, molecular features, and the association between the microenvironmental accumulations of oxidative stress in endometriosis-associated ovarian cancer progression.
Identifiants
pubmed: 30562557
pii: S0891-5849(18)32564-4
doi: 10.1016/j.freeradbiomed.2018.12.015
pii:
doi:
Substances chimiques
Antioxidants
0
Reactive Oxygen Species
0
Iron
E1UOL152H7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-192Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.