Stem cell niche: Dynamic neighbor of stem cells.
Extracellular matrix (ECM)
Hydrogels
Microfluidics
Niche engineering
Stem cell
Journal
European journal of cell biology
ISSN: 1618-1298
Titre abrégé: Eur J Cell Biol
Pays: Germany
ID NLM: 7906240
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
17
08
2018
revised:
09
10
2018
accepted:
11
12
2018
pubmed:
20
12
2018
medline:
15
11
2019
entrez:
20
12
2018
Statut:
ppublish
Résumé
Stem cell niche is a specialized and dynamic microenvironment around the stem cells which plays a critical role in maintaining the stemness properties of stem cells. Over the years, advancement in the research activity has revealed the various important aspects of stem cell niche including cell-cell interaction, cell-extracellular matrix interaction, a large number of soluble signaling factors and various biochemical and biophysical cues (such as oxygen tension, flow, and shear and pore size). Stem cells have the potential to be a powerful tool in regenerative medicine due to their self-renewal property and immense differentiation potential. Recent progresses in in vitro culture conditions of embryonic stem cells, adult stem cells and induced pluripotent stem cells have enabled the researchers to investigate and understand the role of the microenvironment in stem cell properties. The engineered artificial stem cell niche has led to a better execution of stem cells in regenerative medicine. Here we elucidate the key components of stem cell niche and their role in niche engineering and stem cell therapeutics.
Identifiants
pubmed: 30563738
pii: S0171-9335(18)30263-2
doi: 10.1016/j.ejcb.2018.12.001
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
65-73Informations de copyright
Copyright © 2018 Elsevier GmbH. All rights reserved.