Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
02
08
2018
accepted:
13
12
2018
pubmed:
20
12
2018
medline:
17
6
2020
entrez:
20
12
2018
Statut:
ppublish
Résumé
Chronic liver diseases are characterized by the expansion of ductular reaction (DR) cells and the expression of liver progenitor cell (LPC) markers. In alcoholic hepatitis (AH), the degree of DR expansion correlates with disease progression and short-term survival. However, little is known about the biological properties of DR cells, their impact on the pathogenesis of human liver disease, and their contribution to tissue repair. In this study, we have evaluated the transcriptomic profile of DR cells by laser capture microdissection in patients with AH and assessed its association with disease progression. The transcriptome analysis of cytokeratin 7-positive (KRT7
Identifiants
pubmed: 30565271
doi: 10.1002/hep.30472
pmc: PMC9189898
mid: NIHMS1698418
doi:
Substances chimiques
Chemokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2180-2195Subventions
Organisme : Unión Europea
ID : PI17/00673
Pays : International
Organisme : Instituto de Salud Carlos III
ID : CP11/00071
Pays : International
Organisme : H2020 research and innovation programme
ID : 668596
Pays : International
Organisme : Centro de Investigación en Red Enfermedades Hepáticas y Digestivas (CIBERehd)
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI12/01265
Pays : International
Organisme : Instituto de Salud Carlos III
ID : FI16/00203
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI17/00673
Pays : International
Organisme : NIAAA NIH HHS
ID : U01 AA021908
Pays : United States
Organisme : NIAAA NIH HHS
ID : 1U01AA020821
Pays : United States
Organisme : NIAAA NIH HHS
ID : 1U01AA021908
Pays : United States
Organisme : University of Barcelona
Pays : International
Organisme : Unión Europea
ID : PI12/01265
Pays : International
Organisme : NIAAA NIH HHS
ID : U01 AA026972
Pays : United States
Organisme : Instituto de Salud Carlos III
ID : IP13/02340
Pays : International
Organisme : European Foundation for Alcohol Research (ERAB)
ID : EA1653
Pays : International
Organisme : Fondo de Investigación Sanitaria Carlos III (FIS)
Pays : International
Organisme : Unión Europea
ID : PI13/02340
Pays : International
Organisme : Ramón y Cajal program
ID : RYC-2010-07249
Pays : International
Organisme : Fondo Europeo de Desarrollo Regional (FEDER)
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI12/00330
Pays : International
Organisme : Institució Catalana de Recerca i Estudis Avançats (ICREA)
Pays : International
Organisme : Agencia de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)
ID : 2014 SGR 708
Pays : International
Organisme : PhD4MD
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI13/02340
Pays : International
Organisme : MINECO, AGAUR
ID : SGR17-490
Pays : International
Organisme : Unión Europea
ID : PI12/00330
Pays : International
Informations de copyright
© 2018 by the American Association for the Study of Liver Diseases.
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