Synthesis, characterization and biological investigation of platinum(ii) complexes with asparagusic acid derivatives as ligands.
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cisplatin
/ chemistry
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
/ drug effects
Drug Screening Assays, Antitumor
Humans
Ligands
Molecular Structure
Organoplatinum Compounds
/ chemical synthesis
Structure-Activity Relationship
Thiophenes
/ chemistry
Journal
Dalton transactions (Cambridge, England : 2003)
ISSN: 1477-9234
Titre abrégé: Dalton Trans
Pays: England
ID NLM: 101176026
Informations de publication
Date de publication:
15 Jan 2019
15 Jan 2019
Historique:
pubmed:
20
12
2018
medline:
4
4
2019
entrez:
20
12
2018
Statut:
ppublish
Résumé
After more than 50 years of platinum-based anticancer research only three compounds are in clinical use worldwide. The use of the well-known lead compound of this class of anticancer agents, cisplatin, is limited by its side effects and varying resistance mechanisms. Therefore, we report on platinum(ii) compounds with asparagusic acid derivatives as ligands which show interesting anticancer results on cisplatin resistant cell lines.
Substances chimiques
Antineoplastic Agents
0
Ligands
0
Organoplatinum Compounds
0
Thiophenes
0
1,2-dithiolane-4-carboxylic acid
2224-02-4
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM