Seminal human papillomavirus originates from the body surface and is not a frequent aetiological factor in azoospermia.
Vas deferens
azoospermia
human papillomavirus
male genital tract
semen
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
08
08
2018
accepted:
23
10
2018
pubmed:
20
12
2018
medline:
15
6
2019
entrez:
20
12
2018
Statut:
ppublish
Résumé
Human papillomavirus (HPV) DNA has been detected in the testis tissue of 6.5% of 185 men with non-obstructive azoospermia (NOA). Others have suggested that seminal HPV originates from contamination from the genital skin and mucosa. One hundred unselected azoospermic men and 43 normal men undergoing vasectomy were recruited. Testicular biopsies for HPV examination were collected from all the men. Additionally, the normal men undergoing vasectomy delivered a semen sample and had a swab for HPV examination taken from the genital skin before vasectomy. A piece of each Vas deferens obtained during the vasectomy was examined for the presence of HPV. Two of the primarily azoospermic men were shown to have cryptozoospermia. It was not possible to detect HPV in the testis tissue of any of the included 98 azoospermic men or the 43 proven fertile men. In the proven fertile men, HPV DNA was detected in the semen of 15 men (35%), on the genital skin of 28 men (65%), and in the Vas deferens in three cases (7%). In 13 (87%) men with HPV-positive semen samples, HPV DNA was also detected in the skin swabs, and in 11 men (73%), identical HPV genotypes were found in the two locations.
Identifiants
pubmed: 30565706
doi: 10.1111/and.13202
pmc: PMC7379244
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13202Subventions
Organisme : Sanofi Pasteur MSD
Organisme : Aragon Foundation
Organisme : Odense University Hospital
ID : R15-A872
Informations de copyright
© 2018 The Authors. Andrologia Published by Blackwell Verlag GmbH.
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