Multifunctional nanocarriers for the treatment of periodontitis: Immunomodulatory, antimicrobial, and regenerative strategies.
PLGA
bioactive glass
chitosan
nanoparticles
periodontitis
regulatory T lymphocytes
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
26
07
2018
revised:
31
10
2018
accepted:
11
12
2018
pubmed:
20
12
2018
medline:
1
1
2020
entrez:
20
12
2018
Statut:
ppublish
Résumé
Periodontitis is an inflammatory disease, in which the host immuno-inflammatory response against the dysbiotic subgingival biofilm leads to the breakdown of periodontal tissues. Most of the available treatments seem to be effective in the short-term; nevertheless, permanent periodical controls and patient compliance compromise long-term success. Different strategies have been proposed for the modulation of the host immune response as potential therapeutic tools to take a better care of most susceptible periodontitis patients, such as drug local delivery approaches. Though, maintaining an effective drug concentration for a prolonged period of time has not been achieved yet. In this context, advanced drug delivery strategies using biodegradable nanocarriers have been proposed to avoid toxicity and frequency-related problems of treatment. The versatility of distinct nanocarriers allows the improvement of their loading and release capabilities and could be potentially used for microbiological control, periodontal regeneration, and/or immunomodulation. In the present review, we revise and discuss the most frequent biodegradable nanocarrier strategies proposed for the treatment of periodontitis, including polylactic-co-glycolic acid (PLGA), chitosan, and silica-derived nanoparticles, and further suggest novel therapeutic strategies.
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Polylactic Acid-Polyglycolic Acid Copolymer
1SIA8062RS
Chitosan
9012-76-4
Types de publication
Journal Article
Review
Langues
eng
Pagination
1866-1878Subventions
Organisme : CONICYT
Organisme : Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)
ID : FONDECYT 1181780
Informations de copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.
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