Feeling the Force: Measurements of Platelet Contraction and Their Diagnostic Implications.
Journal
Seminars in thrombosis and hemostasis
ISSN: 1098-9064
Titre abrégé: Semin Thromb Hemost
Pays: United States
ID NLM: 0431155
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
pubmed:
20
12
2018
medline:
23
4
2019
entrez:
20
12
2018
Statut:
ppublish
Résumé
In addition to the classical biological and biochemical framework, blood clots can also be considered as active biomaterials composed of dynamically contracting platelets, nascent polymeric fibrin that functions as a matrix scaffold, and entrapped blood cells. As platelets sense, rearrange, and apply forces to the surrounding microenvironment, they dramatically change the material properties of the nascent clot, increasing its stiffness by an order of magnitude. Hence, the mechanical properties of blood clots are intricately tied to the forces applied by individual platelets. Research has also shown that the pathophysiological changes in clot mechanical properties are associated with bleeding and clotting disorders, cancer, stroke, ischemic heart disease, and more. By approaching the study of hemostasis and thrombosis from a biophysical and mechanical perspective, important insights have been made into how the mechanics of clotting and the forces applied by platelets are linked to various diseases. This review will familiarize the reader with a mechanics framework that is contextualized with relevant biology. The review also includes a discussion of relevant tools used to study platelet forces either directly or indirectly, and finally, concludes with a summary of potential links between clotting forces and disease.
Identifiants
pubmed: 30566972
doi: 10.1055/s-0038-1676315
pmc: PMC7284283
mid: NIHMS1022259
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
285-296Subventions
Organisme : NIBIB NIH HHS
ID : R21 EB026591
Pays : United States
Informations de copyright
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Déclaration de conflit d'intérêts
Dr. Myers reports grants from the National Science Foundation (NSF) during the conduct of the study; in addition, Dr. Myers has patent US 14/202,946, pending.Dr. Lam reports grants from National Institutes of Health (NIH), grants from National Science Foundation (NSF), during the conduct of the study; in addition, Dr. Lam has patent US 14/202,949 pending.All the other authors report no conflict of interest.
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