CD36 Enhances Vascular Smooth Muscle Cell Proliferation and Development of Neointimal Hyperplasia.


Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
02 2019
Historique:
pubmed: 21 12 2018
medline: 4 12 2019
entrez: 21 12 2018
Statut: ppublish

Résumé

Objective- Dysregulated proliferation of vascular smooth muscle cells (VSMC) plays an essential role in neointimal hyperplasia. CD36 functions critically in atherogenesis and thrombosis. We hypothesize that CD36 regulates VSMC proliferation and contributes to the development of obstructive vascular diseases. Approach and Results- We found by immunofluorescent staining that CD36 was highly expressed in human vessels with obstructive diseases. Using guidewire-induced carotid artery injury and shear stress-induced intima thickening models, we compared neointimal hyperplasia in Apoe

Identifiants

pubmed: 30567481
doi: 10.1161/ATVBAHA.118.312186
pmc: PMC6345504
mid: NIHMS1516421
doi:

Substances chimiques

CD36 Antigens 0
Cyclin A 0
STAT3 Transcription Factor 0
Stat3 protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

263-275

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL092747
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137004
Pays : United States
Organisme : NHLBI NIH HHS
ID : P50 HL081011
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142152
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130090
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA017748
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103434
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129179
Pays : United States

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Auteurs

Hong Yue (H)

From the Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV (H.Y., A.B., W.L.).

Maria Febbraio (M)

Department of Dentistry, University of Alberta, Edmonton, Canada (M.F.).

Philip A Klenotic (PA)

Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH (P.A.K.).

David J Kennedy (DJ)

Department of Medicine (D.J.K.), University of Toledo, OH.

Yueheng Wu (Y)

Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, China (Y.W., S.C.).

Shaoxian Chen (S)

Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, China (Y.W., S.C.).

Amira F Gohara (AF)

Department of Pathology (A.F.G.), University of Toledo, OH.

Oliver Li (O)

Marshall University Marshall Institute for Interdisciplinary Research, Huntington, WV (O.L., W.L.).

Adam Belcher (A)

From the Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV (H.Y., A.B., W.L.).

Bin Kuang (B)

Department of Plastic and Peripheral Vascular Surgery, Guangdong General Hospital, China (B.K.).

Thomas M McIntyre (TM)

Departments of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, OH (T.M.M.).
Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH (T.M.M.).

Roy L Silverstein (RL)

Department of Medicine, Medical College of Wisconsin, Milwaukee (R.L.S.).

Wei Li (W)

From the Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV (H.Y., A.B., W.L.).

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Classifications MeSH