Hibernating astronauts-science or fiction?
Hibernation
Metabolism
Spaceflight
Torpor
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
29
06
2018
accepted:
03
12
2018
revised:
29
11
2018
pubmed:
21
12
2018
medline:
6
5
2020
entrez:
21
12
2018
Statut:
ppublish
Résumé
For long-duration manned space missions to Mars and beyond, reduction of astronaut metabolism by torpor, the metabolic state during hibernation of animals, would be a game changer: Water and food intake could be reduced by up to 75% and thus reducing payload of the spacecraft. Metabolic rate reduction in natural torpor is linked to profound changes in biochemical processes, i.e., shift from glycolysis to lipolysis and ketone utilization, intensive but reversible alterations in organs like the brain and kidney, and in heart rate control via Ca
Identifiants
pubmed: 30569200
doi: 10.1007/s00424-018-2244-7
pii: 10.1007/s00424-018-2244-7
pmc: PMC6533228
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
819-828Références
Comp Biochem Physiol. 1970 Jan 15;32(2):155-60
pubmed: 5417450
J Appl Physiol (1985). 2016 Apr 15;120(8):947-55
pubmed: 26769956
Physiol Res. 2016 Sep 19;65 Suppl 1:S55-64
pubmed: 27643940
Acta Physiol (Oxf). 2017 Feb;219(2):409-440
pubmed: 27364602
Clin Transl Sci. 2015 Oct;8(5):601-5
pubmed: 26083277
J Comp Physiol B. 2015 Apr;185(3):265-79
pubmed: 25542162
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2052-7
pubmed: 21245336
Anesthesiology. 2016 Jun;124(6):1296-310
pubmed: 27187119
J Exp Biol. 2016 Jan;219(Pt 2):226-34
pubmed: 26792334
Comp Biochem Physiol B Biochem Mol Biol. 2018 May;219-220:1-9
pubmed: 29501789
Radiat Res. 1968 Feb;33(2):348-56
pubmed: 5637298
Physiology (Bethesda). 2013 Sep;28(5):284-97
pubmed: 23997188
Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18775-80
pubmed: 17121986
Int J Cardiol. 2011 Feb 3;146(3):442-3
pubmed: 21130509
Nature. 2004 Jun 24;429(6994):825-6
pubmed: 15215852
Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R383-93
pubmed: 19052316
Nature. 2015 Feb 12;518(7538):236-9
pubmed: 25607368
J Comp Physiol B. 2010 Aug;180(6):869-76
pubmed: 20217093
J Exp Biol. 2005 Apr;208(Pt 7):1373-83
pubmed: 15781897
Life Sci. 2014 Mar 3;97(2):123-8
pubmed: 24361401
Am J Physiol. 1998 Nov;275(5):R1627-32
pubmed: 9791083
J Appl Physiol (1985). 2016 Apr 15;120(8):891-903
pubmed: 26893033
Pharmacol Res. 2013 Aug;74:34-44
pubmed: 23702336
Comp Biochem Physiol A Comp Physiol. 1972 Feb 1;41(2):349-59
pubmed: 4404314
Transplant Rev (Orlando). 2016 Jan;30(1):13-9
pubmed: 26613668
Cochrane Database Syst Rev. 2017 Sep 21;9:CD001048
pubmed: 28933514
PLoS One. 2008;3(12):e4038
pubmed: 19107190
Am J Physiol Regul Integr Comp Physiol. 2014 Dec 1;307(11):R1324-9
pubmed: 25253085
J Appl Physiol (1985). 2016 Jun 15;120(12):1449-57
pubmed: 26846554
Annu Rev Physiol. 2017 Feb 10;79:167-186
pubmed: 27813827
Lancet. 2003 Sep 27;362(9389):1028-37
pubmed: 14522533
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5472-80
pubmed: 27573827
Physiol Behav. 2009 Aug 4;98(1-2):78-84
pubmed: 19393672
Neurosci Lett. 1991 Jul 22;128(2):265-8
pubmed: 1945046
Basic Res Cardiol. 2016 Nov;111(6):70
pubmed: 27766474
J Neurochem. 2009 Apr;109(1):257-67
pubmed: 19200349
Biochem Soc Trans. 2004 Dec;32(Pt 6):1021-4
pubmed: 15506953
Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1999-2014
pubmed: 18843088
Behav Brain Res. 2006 Feb 15;167(1):128-33
pubmed: 16219369
Cochrane Database Syst Rev. 2016 Mar 22;3:CD008445
pubmed: 27000210
Cell Stem Cell. 2014 Jun 5;14(6):810-23
pubmed: 24905167
J Neurochem. 2015 Dec;135(5):943-57
pubmed: 26375300
Life Sci Space Res (Amst). 2018 Feb;16:101-107
pubmed: 29475515
Thorac Cardiovasc Surg. 1990 Aug;38(4):212-9
pubmed: 2237881
PLoS One. 2011;6(7):e22568
pubmed: 21829469
Integr Comp Biol. 2014 Sep;54(3):497-515
pubmed: 24848803
Am J Physiol. 1999 May;276(5):E896-906
pubmed: 10329984
Annu Rev Physiol. 2004;66:239-74
pubmed: 14977403
Curr Opin Crit Care. 2009 Oct;15(5):431-6
pubmed: 19617821
J Comp Physiol B. 2013 May;183(4):567-81
pubmed: 23212435
Comp Biochem Physiol A Mol Integr Physiol. 1999 Jul;123(3):221-34
pubmed: 10501017
J Comp Physiol B. 2002 Jul;172(5):355-61
pubmed: 12122451
Neuroscience. 1992;48(1):53-62
pubmed: 1584425
J Exp Biol. 2014 Apr 1;217(Pt 7):1024-39
pubmed: 24671961
J Physiol Sci. 2018 Jul;68(4):425-430
pubmed: 28508339
J Neurosci. 2013 Feb 13;33(7):2984-93
pubmed: 23407956
Eur J Neurosci. 2007 Nov;26(10):2739-46
pubmed: 18001271
Cochrane Database Syst Rev. 2015 Jan 28;1:CD006638
pubmed: 25626888
Biol Rev Camb Philos Soc. 2015 Aug;90(3):891-926
pubmed: 25123049
J Cell Physiol. 2012 Apr;227(4):1285-90
pubmed: 21618525
Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R234-5
pubmed: 17989134
J Proteome Res. 2017 Feb 3;16(2):958-969
pubmed: 27991798
PLoS One. 2011 Jan 18;6(1):e14530
pubmed: 21267079
J Neurophysiol. 2002 Nov;88(5):2280-6
pubmed: 12424269
PPAR Res. 2009;2009:412949
pubmed: 19536348
Eur J Pharmacol. 2015 Dec 15;769:225-33
pubmed: 26593431
Cell Metab. 2014 May 6;19(5):741-756
pubmed: 24630813
Thorac Cardiovasc Surg. 1990 Aug;38(4):205-11
pubmed: 2237880
Adv Exp Med Biol. 2018;1081:45-60
pubmed: 30288703
Brain Res. 2007 Aug 3;1161:38-45
pubmed: 17583682
Pharmacol Ther. 1984;25(3):371-93
pubmed: 6514772
Am J Physiol. 1991 Jun;260(6 Pt 2):R1123-9
pubmed: 2058740
Wiley Interdiscip Rev RNA. 2018 Mar;9(2):
pubmed: 29322631
Science. 2011 Feb 18;331(6019):906-9
pubmed: 21330544
Naturwissenschaften. 1997 Jan;84(1):28-32
pubmed: 9050004
Science. 2005 Apr 22;308(5721):518
pubmed: 15845845
Nat Rev Cancer. 2011 Jun;11(6):393-410
pubmed: 21606941
J Exp Biol. 2014 Nov 15;217(Pt 22):4043-8
pubmed: 25392460
Physiol Rev. 2003 Oct;83(4):1153-81
pubmed: 14506303
Am J Physiol Regul Integr Comp Physiol. 2005 Aug;289(2):R586-R595
pubmed: 15831769
Exp Physiol. 2014 Apr;99(4):632-7
pubmed: 24443348
J Cereb Blood Flow Metab. 2010 Sep;30(9):1598-607
pubmed: 20407465
Bone. 2009 Dec;45(6):1186-91
pubmed: 19703606
Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R1833-45
pubmed: 17804585
Stroke. 2016 Apr;47(4):1085-93
pubmed: 26979866
Oecologia. 1981 Mar;48(2):265-270
pubmed: 28309811
Int J Radiat Biol. 2014 Apr;90(4):318-24
pubmed: 24467331
J Exp Biol. 2016 Sep 1;219(Pt 17):2582-95
pubmed: 27582559
Respir Physiol Neurobiol. 2004 Aug 12;141(3):317-29
pubmed: 15288602
Clin Neurophysiol. 2013 Mar;124(3):589-97
pubmed: 23063293
Sci Transl Med. 2017 Feb 15;9(377):
pubmed: 28202775
Anticancer Agents Med Chem. 2017;17(4):472-482
pubmed: 27592547
Life Sci Space Res (Amst). 2016 Nov;11:1-9
pubmed: 27993187
Am J Physiol. 1999 Feb;276(2):R522-9
pubmed: 9950933
Front Zool. 2016 Feb 11;13:7
pubmed: 26870151
Comp Biochem Physiol B Biochem Mol Biol. 2012 May;162(1-3):1-9
pubmed: 22326449
J Cereb Blood Flow Metab. 2007 May;27(5):950-62
pubmed: 16955077
J Exp Biol. 2011 Apr 15;214(Pt 8):1276-82
pubmed: 21430204
J Cereb Blood Flow Metab. 1998 Feb;18(2):168-75
pubmed: 9469159
Biomol Concepts. 2016 Feb;7(1):41-52
pubmed: 26820181
J Comp Physiol B. 2000 Nov;170(7):551-9
pubmed: 11128446
Naturwissenschaften. 2007 Nov;94(11):941-4
pubmed: 17607555
J Neuroendocrinol. 2016 Nov;28(11):
pubmed: 27755687
J Comp Physiol B. 2008 Feb;178(2):167-77
pubmed: 17912534
J Comp Physiol B. 2017 Jul;187(5-6):793-802
pubmed: 28389695
Cryobiology. 2010 Apr;60(2):198-203
pubmed: 19913528
J Appl Physiol (1985). 2009 Jan;106(1):284-92
pubmed: 18974367
J Biol Chem. 2016 Oct 21;291(43):22509-22523
pubmed: 27609515
Am J Physiol Regul Integr Comp Physiol. 2006 Nov;291(5):R1303-9
pubmed: 16825418
Physiol Biochem Zool. 2008 Jul-Aug;81(4):442-51
pubmed: 18507533
Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R329-40
pubmed: 19923364
Eur J Neurosci. 2004 Sep;20(5):1363-70
pubmed: 15341608