Dopamine and addiction: what have we learned from 40 years of research.
Neuroplasticity
Reward
Striatum
Substance abuse
Substantia nigra
Treatment
VTA
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
06
11
2018
accepted:
17
11
2018
pubmed:
21
12
2018
medline:
27
6
2020
entrez:
21
12
2018
Statut:
ppublish
Résumé
Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known. The critical role of DA in addiction is supported by converging evidence that has been accumulated in the last 40 years. In the present review, first we describe the dopaminergic system in terms of connectivity, functioning and involvement in reward processes. Second, we describe the functional, structural, and molecular changes induced by drugs within the DA system in terms of neuronal activity, synaptic plasticity and transcriptional and molecular adaptations. Third, we describe how genetic mouse models have helped characterizing the role of DA in addiction. Fourth, we describe the involvement of the DA system in the vulnerability to addiction and the interesting case of addiction DA replacement therapy in Parkinson's disease. Finally, we describe how the DA system has been targeted to treat patients suffering from addiction and the result obtained in clinical settings and we discuss how these different lines of evidence have been instrumental in shaping our understanding of the physiopathology of drug addiction.
Identifiants
pubmed: 30569209
doi: 10.1007/s00702-018-1957-2
pii: 10.1007/s00702-018-1957-2
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
481-516Références
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