Interethnic scaling of fraction unbound of a drug in plasma and volume of distribution: an analysis of extrapolation from Caucasians to Chinese.
Clinical pharmacokinetics
Fraction unbound
Healthy subjects
Interethnic scaling
Volume of distribution
Journal
European journal of clinical pharmacology
ISSN: 1432-1041
Titre abrégé: Eur J Clin Pharmacol
Pays: Germany
ID NLM: 1256165
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
10
07
2018
accepted:
10
12
2018
pubmed:
21
12
2018
medline:
7
9
2019
entrez:
21
12
2018
Statut:
ppublish
Résumé
Prospective prediction of pharmacokinetic properties for individuals of different ethnic groups could provide useful information for the design of multiregional clinical trials. The accuracy of interethnic scaling of fraction unbound (f This study assessed the interethnic scaling of f The interethnic extrapolation approach of f The current study verified for the first time the ability to scale Chinese f
Identifiants
pubmed: 30569284
doi: 10.1007/s00228-018-02610-z
pii: 10.1007/s00228-018-02610-z
doi:
Substances chimiques
Blood Proteins
0
Glycoproteins
0
Orosomucoid
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
543-551Subventions
Organisme : National Natural Science Foundation of China
ID : 81603209
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