Small-fiber neuropathy: Expanding the clinical pain universe.
diagnostic criteria
neuropathic pain
pain management
small-fiber neuropathy
sodium channel variants
Journal
Journal of the peripheral nervous system : JPNS
ISSN: 1529-8027
Titre abrégé: J Peripher Nerv Syst
Pays: United States
ID NLM: 9704532
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
01
10
2018
revised:
27
11
2018
accepted:
14
12
2018
pubmed:
21
12
2018
medline:
5
6
2020
entrez:
21
12
2018
Statut:
ppublish
Résumé
Small-fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to a significant reduction in quality of life. According to international criteria, the diagnosis is established by the assessment of intraepidermal nerve fiber density and/or quantitative sensory testing. SFN is mainly associated with autoimmune diseases, sodium channel gene variants, diabetes mellitus, and vitamin B12 deficiencies, although in more than one half of patients no etiology can be identified. Recently, gain-of-function variants in the genes encoding for the Na
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-33Informations de copyright
© 2018 Peripheral Nerve Society.