Effect of maternal obesity on fetal and postnatal baboon (Papio species) early life phenotype.
ACTH
baboon
cortisol
developmental programming
fructose
high-energy diet
high-fat diet
maternal nutrition
non-human primates
Journal
Journal of medical primatology
ISSN: 1600-0684
Titre abrégé: J Med Primatol
Pays: Denmark
ID NLM: 0320626
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
31
05
2018
revised:
25
09
2018
accepted:
16
11
2018
pubmed:
21
12
2018
medline:
16
4
2020
entrez:
21
12
2018
Statut:
ppublish
Résumé
Non-human primate models of developmental programming by maternal obesity (MO) are needed for translation to human programming outcomes. We present baboon offspring (F1) morphometry, blood cortisol, and adrenocorticotropic hormone (ACTH) from 0.9 gestation to 0-2 years. Control mothers ate chow; MO mothers ate high-fat high-energy diet pre-pregnancy through lactation. Maternal obesity mothers weighed more than controls pre-pregnancy. Maternal obesity gestational weight gain was lower with no correlation with fetal or placenta weights. At 0.9 gestation, MO and control F1 morphometry and ACTH were similar. MO-F1 0.9 gestation male cortisol was lower, rising slower from 0-2 years vs control-F1. At birth, male MO-F1 and control-F1 weights were similar, but growth from 0-2 years was steeper in MO-F1; newborn female MO-F1 weighed more than control-F1 but growth from 0-2 years was similar. ACTH did not change in either sex. Maternal obesity produced sexually dimorphic fetal and postnatal growth and hormonal phenotypes.
Sections du résumé
BACKGROUND
Non-human primate models of developmental programming by maternal obesity (MO) are needed for translation to human programming outcomes. We present baboon offspring (F1) morphometry, blood cortisol, and adrenocorticotropic hormone (ACTH) from 0.9 gestation to 0-2 years.
METHODS
Control mothers ate chow; MO mothers ate high-fat high-energy diet pre-pregnancy through lactation.
RESULTS
Maternal obesity mothers weighed more than controls pre-pregnancy. Maternal obesity gestational weight gain was lower with no correlation with fetal or placenta weights. At 0.9 gestation, MO and control F1 morphometry and ACTH were similar. MO-F1 0.9 gestation male cortisol was lower, rising slower from 0-2 years vs control-F1. At birth, male MO-F1 and control-F1 weights were similar, but growth from 0-2 years was steeper in MO-F1; newborn female MO-F1 weighed more than control-F1 but growth from 0-2 years was similar. ACTH did not change in either sex.
CONCLUSIONS
Maternal obesity produced sexually dimorphic fetal and postnatal growth and hormonal phenotypes.
Identifiants
pubmed: 30569595
doi: 10.1111/jmp.12396
pmc: PMC6598713
mid: NIHMS1037333
doi:
Substances chimiques
Adrenocorticotropic Hormone
9002-60-2
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-98Subventions
Organisme : NICHD NIH HHS
ID : P01 HD021350
Pays : United States
Organisme : NIH HHS
ID : P51 OD011133
Pays : United States
Organisme : NIH HHS
ID : R24 OD010916
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG057758
Pays : United States
Informations de copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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