Effects of Intermittent Versus Continuous Energy Intakes on Insulin Sensitivity and Metabolic Risk in Women with Overweight.

Energy Intake / physiology Fasting / physiology Female Humans Insulin Resistance Metabolism Middle Aged Overweight / therapy

Journal

Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860

Informations de publication

Date de publication:
01 2019
Historique:
received: 11 04 2018
revised: 06 09 2018
accepted: 18 09 2018
entrez: 21 12 2018
pubmed: 21 12 2018
medline: 16 1 2020
Statut: ppublish

Résumé

This study aimed to compare intermittent fasting (IF) versus continuous energy intakes at 100% or 70% of calculated energy requirements on insulin sensitivity, cardiometabolic risk, body weight, and composition. Women with overweight (n = 88; 50 ± 1 years, BMI 32.3 ± 0.5 kg/m IF70 displayed greater reductions in weight, fat mass, total- and low-density lipoprotein cholesterol, and nonesterified fatty acids compared with DR70 and IF100 (all P ≤ 0.05). IF100 lost more weight and fat than control. However, fasting insulin was increased. There were no group differences in insulin sensitivity by clamp; however, a 24-hour fast transiently reduced insulin sensitivity. When prescribed at matched energy restriction, IF reduced weight and fat mass and improved total and low-density lipoprotein cholesterol more than DR. IF prescribed in energy balance did not improve health compared with other groups, despite modest weight loss.

Identifiants

DOI: 10.1002/oby.22345 PMID: 30569640
pubmed: 30569640
doi: 10.1002/oby.22345
doi:

Banques de données

ClinicalTrials.gov
['NCT01769976']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

50-58

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2018 The Obesity Society.

Auteurs

Amy T Hutchison (AT)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Bo Liu (B)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Rachel E Wood (RE)

School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.

Andrew D Vincent (AD)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Campbell H Thompson (CH)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Nathan J O'Callaghan (NJ)

Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Commonwealth Scientific and Industrial Research Organization (CSIRO) Food, Nutrition and Bioproducts Flagship, Adelaide, South Australia, Australia.

Gary A Wittert (GA)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Leonie K Heilbronn (LK)

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
Nutrition and Metabolism Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Ration calorique › Effects of Intermittent Versus Continuous...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Comportement alimentaire › Jeûne › Effects of Intermittent Versus Continuous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effects of Intermittent Versus Continuous...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Effects of Intermittent Versus Continuous...
questionsmedicales.fr › Métabolisme › Effects of Intermittent Versus Continuous...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Effects of Intermittent Versus Continuous...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Apparence corporelle › Surpoids › Effects of Intermittent Versus Continuous...