Ionotropic and metabotropic kainate receptor signalling regulates Cl

Animals CA1 Region, Hippocampal / cytology CA3 Region, Hippocampal / cytology Cells, Cultured Chlorides / metabolism Female Homeostasis Inhibitory Postsynaptic Potentials Male Mice Mice, Inbred C57BL Mossy Fibers, Hippocampal / metabolism Pyramidal Cells / metabolism Receptors, GABA / metabolism Receptors, Kainic Acid / metabolism Symporters / metabolism K Cl- Cotransporters GluK2 Kainate Receptor
Chloride transport GABA KCC2 Kainate receptor electrophysiology hippocampus ionotropic metabotropic

Journal

The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262

Informations de publication

Date de publication:
03 2019
Historique:
received: 31 07 2018
accepted: 19 12 2018
pubmed: 21 12 2018
medline: 10 7 2020
entrez: 21 12 2018
Statut: ppublish

Résumé

Potassium-chloride co-transporter 2 (KCC2) plays a critical role in regulating chloride homeostasis, which is essential for hyperpolarizing inhibition in the mature nervous system. KCC2 interacts with many proteins involved in excitatory neurotransmission, including the GluK2 subunit of the kainate receptor (KAR). We show that activation of KARs hyperpolarizes the reversal potential for GABA (E Potassium-chloride co-transporter 2 (KCC2) plays a critical role in the regulation of chloride (Cl

Identifiants

DOI: 10.1113/JP276901 PMID: 30570751 PMC: PMC6418771
pubmed: 30570751
doi: 10.1113/JP276901
pmc: PMC6418771
doi:

Substances chimiques

Chlorides 0
Gluk1 kainate receptor 0
Receptors, GABA 0
Receptors, Kainic Acid 0
Symporters 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1677-1690

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society.

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Auteurs

Danielle Garand (D)

Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.

Vivek Mahadevan (V)

Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
ORCID: 0000-0002-0805-827X

Melanie A Woodin (MA)

Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
ORCID: 0000-0003-2984-8630

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Région CA1 de l'hippocampe › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Région CA3 de l'hippocampe › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Cellules › Cellules cultivées › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques inhibiteurs › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Fibres moussues de l'hippocampe › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Cellules › Neurones › Cellules pyramidales › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteurs kaïnate › Ionotropic and metabotropic kainate receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Symporteurs › Ionotropic and metabotropic kainate receptor...