Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer.
Immunohistochemistry
Lung cancer
Neuroendocrine markers
TTF1
p40
Journal
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
ISSN: 1556-1380
Titre abrégé: J Thorac Oncol
Pays: United States
ID NLM: 101274235
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
07
11
2018
revised:
03
12
2018
accepted:
05
12
2018
pubmed:
21
12
2018
medline:
17
4
2020
entrez:
21
12
2018
Statut:
ppublish
Résumé
Since the 2015 WHO classification was introduced into clinical practice, immunohistochemistry (IHC) has figured prominently in lung cancer diagnosis. In addition to distinction of small cell versus non-small cell carcinoma, patients' treatment of choice is directly linked to histologic subtypes of non-small cell carcinoma, which pertains to IHC results, particularly for poorly differentiated tumors. The use of IHC has improved diagnostic accuracy in the classification of lung carcinoma, but the interpretation of IHC results remains challenging in some instances. Also, pathologists must be aware of many interpretation pitfalls, and the use of IHC should be efficient to spare the tissue for molecular testing. The International Association for the Study of Lung Cancer Pathology Committee received questions on practical application and interpretation of IHC in lung cancer diagnosis. After discussions in several International Association for the Study of Lung Cancer Pathology Committee meetings, the issues and caveats were summarized in terms of 11 key questions covering common and important diagnostic situations in a daily clinical practice with some relevant challenging queries. The questions cover topics such as the best IHC markers for distinguishing NSCLC subtypes, differences in thyroid transcription factor 1 clones, and the utility of IHC in diagnosing uncommon subtypes of lung cancer and distinguishing primary from metastatic tumors. This article provides answers and explanations for the key questions about the use of IHC in diagnosis of lung carcinoma, representing viewpoints of experts in thoracic pathology that should assist the community in the appropriate use of IHC in diagnostic pathology.
Identifiants
pubmed: 30572031
pii: S1556-0864(18)33514-7
doi: 10.1016/j.jtho.2018.12.005
pmc: PMC6422775
mid: NIHMS1516887
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
377-407Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
Copyright © 2018 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
Références
J Clin Pathol. 2004 Apr;57(4):383-7
pubmed: 15047742
Br J Cancer. 2004 Dec 13;91(12):2018-25
pubmed: 15545971
Am J Surg Pathol. 2013 Feb;37(2):211-8
pubmed: 23108025
Int J Surg Pathol. 2014 Aug;22(5):401-7
pubmed: 24651909
Hum Pathol. 2009 Mar;40(3):366-73
pubmed: 18973918
Arch Pathol Lab Med. 2015 Apr;139(4):434-6
pubmed: 25521803
Appl Immunohistochem Mol Morphol. 2017 Aug;25(7):453-459
pubmed: 28549039
Mod Pathol. 2004 Jul;17(7):765-71
pubmed: 15105807
Hum Pathol. 2017 Sep;67:205-210
pubmed: 28843711
Am J Pathol. 1994 Aug;145(2):268-75
pubmed: 7519823
Mod Pathol. 2017 Oct;30(10):1422-1432
pubmed: 28643792
Arch Pathol Lab Med. 2017 Feb;141(2):288-292
pubmed: 27628324
Hum Pathol. 2015 Nov;46(11):1592-7
pubmed: 26342243
Pathol Res Pract. 2005;201(8-9):579-86
pubmed: 16259111
Cytopathology. 2008 Aug;19(4):205-11
pubmed: 17573908
J Thorac Oncol. 2017 Jun;12(6):932-942
pubmed: 28315738
J Thorac Oncol. 2015 Oct;10(10):1500-2
pubmed: 26398824
Mod Pathol. 2012 Aug;25(8):1117-27
pubmed: 22499226
Pathol Int. 2018 Feb;68(2):128-132
pubmed: 29316066
Hum Pathol. 2017 Sep;67:160-168
pubmed: 28782639
Mod Pathol. 2004 Feb;17(2):222-9
pubmed: 14657947
Pathol Res Pract. 2014 Oct;210(10):680-5
pubmed: 25063315
Dis Chest. 1967 Aug;52(2):147-52
pubmed: 6068432
Hum Pathol. 2017 Jan;59:1-9
pubmed: 27569293
Am J Clin Pathol. 2015 Oct;144(4):579-91
pubmed: 26386079
Elife. 2016 Mar 07;5:e13722
pubmed: 26949251
Am J Clin Pathol. 2001 Sep;116(3):319-25
pubmed: 11554157
Cytopathology. 2014 Dec;25(6):356-71
pubmed: 25113785
Virchows Arch. 2015 Jul;467(1):119-21
pubmed: 25838079
Am J Surg Pathol. 2012 Jun;36(6):895-9
pubmed: 22367298
J Clin Oncol. 2016 Mar 10;34(8):794-802
pubmed: 26215952
Cytopathology. 2011 Aug;22(4):230-7
pubmed: 21518045
Am J Surg Pathol. 2015 Sep;39(9):1170-80
pubmed: 25871623
Hum Pathol. 2010 Apr;41(4):560-5
pubmed: 20004952
Histopathology. 2014 Dec;65(6):868-78
pubmed: 25130792
Hum Pathol. 2018 Sep;79:122-126
pubmed: 29802871
Hum Pathol. 2016 Feb;48:142-7
pubmed: 26596584
Am J Surg Pathol. 2016 May;40(5):714-8
pubmed: 26900815
Hum Pathol. 2018 Aug;78:177-181
pubmed: 29410129
Nature. 1997 Apr 24;386(6627):852-5
pubmed: 9126746
Histopathology. 2012 Dec;61(6):1017-25
pubmed: 22882703
Clin Transl Med. 2015 Apr 21;4:16
pubmed: 25977750
Int J Clin Exp Pathol. 2014 Jun 15;7(7):4247-53
pubmed: 25120805
Am J Clin Pathol. 2012 Nov;138(5):703-11
pubmed: 23086771
Acta Cytol. 2012;56(3):289-96
pubmed: 22555532
Cancer. 2003 Feb 25;99(1):51-6
pubmed: 12589646
Am J Surg Pathol. 2015 Jan;39(1):13-24
pubmed: 25353284
Am J Surg Pathol. 2014 Apr;38(4):552-9
pubmed: 24625420
Appl Immunohistochem Mol Morphol. 2015 Apr;23(4):297-302
pubmed: 25265430
Cancer Cytopathol. 2010 Dec 25;118(6):441-9
pubmed: 20830690
J Thorac Oncol. 2013 Aug;8(8):1004-11
pubmed: 23689429
Am J Surg Pathol. 2011 Jan;35(1):15-25
pubmed: 21164283
Am J Surg Pathol. 2002 Sep;26(9):1184-97
pubmed: 12218575
Ann Diagn Pathol. 2004 Oct;8(5):259-67
pubmed: 15494931
Hum Pathol. 2017 May;63:14-26
pubmed: 27993578
Am J Surg Pathol. 2017 Sep;41(9):1221-1225
pubmed: 28614203
Am J Surg Pathol. 2001 Dec;25(12):1515-9
pubmed: 11717541
Pathol Int. 2015 Jun;65(6):286-92
pubmed: 25727644
Am J Surg Pathol. 1987 Apr;11(4):241-7
pubmed: 3032010
Mod Pathol. 2018 Dec;31(12):1770-1786
pubmed: 30140036
Hum Pathol. 2006 May;37(5):542-6
pubmed: 16647951
BMJ Open. 2012 Oct 12;2(5):
pubmed: 23065444
Appl Immunohistochem Mol Morphol. 2012 Oct;20(5):429-44
pubmed: 22531688
J Pathol. 2004 Jun;203(2):645-52
pubmed: 15141379
Br J Cancer. 2003 Apr 22;88(8):1229-33
pubmed: 12698189
Am J Clin Pathol. 2011 Jul;136(1):81-7
pubmed: 21685035
Histopathology. 2011 Jul;59(1):145-8
pubmed: 21771032
Virchows Arch. 2011 Dec;459(6):615-21
pubmed: 22071579
Adv Anat Pathol. 2012 Jan;19(1):66-73
pubmed: 22156835
Mod Pathol. 2000 Mar;13(3):238-42
pubmed: 10757334
J Thorac Oncol. 2015 Jun;10(6):951-9
pubmed: 26001144
Am J Surg Pathol. 2011 Aug;35(8):1226-34
pubmed: 21753699
Am J Surg Pathol. 2010 Dec;34(12):1881-5
pubmed: 21107096
Mod Pathol. 2011 Oct;24(10):1348-59
pubmed: 21623384
Cancer Discov. 2014 Aug;4(8):889-95
pubmed: 24875859
Appl Immunohistochem Mol Morphol. 2016 Oct;24(9):648-659
pubmed: 26447895
Am J Clin Pathol. 2013 Feb;139(2):160-6
pubmed: 23355200
Hum Pathol. 2018 Apr;74:109-113
pubmed: 29104113
Lung Cancer. 2010 May;68(2):185-91
pubmed: 19581016
Am J Surg Pathol. 2012 Aug;36(8):1222-7
pubmed: 22790861
Mod Pathol. 2014 Mar;27(3):390-5
pubmed: 24030747
Cancer Res. 2017 May 15;77(10):2722-2734
pubmed: 28283655
Mod Pathol. 2006 Oct;19(10):1358-68
pubmed: 16862075
Int J Gynecol Pathol. 2009 Jan;28(1):10-8
pubmed: 19047914
Cancer Cytopathol. 2016 Nov;124(11):828-835
pubmed: 27315045
Arch Pathol Lab Med. 2016 Dec;140(12):1318-1322
pubmed: 27557411
Hum Pathol. 2018 Oct;80:163-169
pubmed: 29894722
Am J Clin Pathol. 2011 Aug;136(2):252-9
pubmed: 21757598
Am J Clin Pathol. 2014 Sep;142(3):320-4
pubmed: 25125621
Cytopathology. 2011 Aug;22(4):238-42
pubmed: 21771093
Arch Pathol Lab Med. 2010 Nov;134(11):1645-58
pubmed: 21043818
J Thorac Oncol. 2016 Feb;11(2):e26-7
pubmed: 26811228
Appl Immunohistochem Mol Morphol. 2005 Mar;13(1):55-60
pubmed: 15722794
J Thorac Oncol. 2017 Feb;12(2):334-346
pubmed: 27998793
Mod Pathol. 2013 Apr;26(4):511-22
pubmed: 23196793
Cancer. 1972 Feb;29(2):501-8
pubmed: 4111143
Arch Pathol Lab Med. 2016 Dec;140(12):1331-1337
pubmed: 27588333
Mod Pathol. 2014 Nov;27(11):1479-88
pubmed: 24743219
Mod Pathol. 2012 Mar;25(3):405-15
pubmed: 22056955
J Thorac Oncol. 2014 Mar;9(3):273-84
pubmed: 24518085
J Thorac Oncol. 2016 Apr;11(4):e49-51
pubmed: 26746366
Am J Surg Pathol. 2010 Aug;34(8):1097-105
pubmed: 20588175
Am J Surg Pathol. 2012 Jan;36(1):142-8
pubmed: 22173119
Arch Pathol Lab Med. 2015 Jan;139(1):55-66
pubmed: 25549144
Diagn Cytopathol. 2011 Mar;39(3):159-67
pubmed: 21319315
Histopathology. 2014 Oct;65(4):465-72
pubmed: 24592933
Cytopathology. 2017 Oct;28(5):371-377
pubmed: 28730709
J Surg Oncol. 2014 Mar;109(3):280-6
pubmed: 24301337
Am J Surg Pathol. 2017 Jul;41(7):915-922
pubmed: 28498280
Clin Cancer Res. 2009 Sep 1;15(17):5359-68
pubmed: 19706809
Carcinogenesis. 2014 Jun;35(6):1267-75
pubmed: 24523449
Mod Pathol. 2014 Feb;27(2):262-70
pubmed: 23887294
Am J Surg Pathol. 2000 Jun;24(6):761-74
pubmed: 10843278
J Pathol. 2006 May;209(1):78-87
pubmed: 16463270
Diagn Cytopathol. 2012 Nov;40(11):949-55
pubmed: 21500373
Am J Surg Pathol. 2014 Jan;38(1):13-22
pubmed: 24145643
Mod Pathol. 2007 Feb;20(2):208-14
pubmed: 17192791
Virchows Arch. 2017 Jun;470(6):619-626
pubmed: 28343305
Am J Surg Pathol. 2008 Mar;32(3):426-32
pubmed: 18300807
Am J Surg Pathol. 2015 Jul;39(7):957-67
pubmed: 25723109
Arch Pathol Lab Med. 2014 Sep;138(9):1167-72
pubmed: 24840035
Arch Pathol Lab Med. 2018 Apr;142(4):529-535
pubmed: 29095036
Virchows Arch. 2009 Aug;455(2):125-32
pubmed: 19652998
Virchows Arch. 2014 Jan;464(1):61-8
pubmed: 24221342
Arch Pathol Lab Med. 2014 May;138(5):626-35
pubmed: 23738762
Arch Pathol Lab Med. 2013 May;137(5):632-6
pubmed: 23627453
Nat Genet. 2015 Oct;47(10):1200-5
pubmed: 26343384
Am J Surg Pathol. 2007 Jan;31(1):26-32
pubmed: 17197916
Appl Immunohistochem Mol Morphol. 2016 Jan;24(1):57-63
pubmed: 25710581
Mod Pathol. 2014 Apr;27(4):535-42
pubmed: 24030743
Appl Immunohistochem Mol Morphol. 2002 Jun;10(2):97-102
pubmed: 12051643
Virchows Arch. 2015 Dec;467(6):675-686
pubmed: 26450556
J Thorac Oncol. 2015 Nov;10(11):1560-9
pubmed: 26317919
Mod Pathol. 2002 May;15(5):538-42
pubmed: 12011259
Appl Immunohistochem Mol Morphol. 2015 Nov-Dec;23(10):711-6
pubmed: 25611245
Am J Surg Pathol. 2012 Oct;36(10):1472-6
pubmed: 22982890
Histopathology. 2014 Mar;64(4):504-11
pubmed: 24111789
J Urol. 2014 Mar;191(3):603-10
pubmed: 24076305
Hum Pathol. 2016 Oct;56:134-42
pubmed: 27327192
Am J Surg Pathol. 2017 Nov;41(11):1561-1569
pubmed: 28719469
Hum Pathol. 2000 Aug;31(8):980-7
pubmed: 10987260
Am J Surg Pathol. 2009 Apr;33(4):513-20
pubmed: 19145203
J Surg Res. 2010 Sep;163(1):47-51
pubmed: 20599218
J Thorac Oncol. 2015 Nov;10(11):1570-5
pubmed: 26309189
Am J Surg Pathol. 2016 Feb;40(2):212-23
pubmed: 26645726
Am J Clin Pathol. 2007 Jan;127(1):103-13
pubmed: 17145637
J Thorac Oncol. 2014 Aug;9(8):1126-39
pubmed: 24942260
Arch Pathol Lab Med. 2008 Feb;132(2):239-43
pubmed: 18251583
Am J Surg Pathol. 2009 Apr;33(4):626-32
pubmed: 19065104
Histopathology. 2001 Oct;39(4):397-401
pubmed: 11683941
J Clin Pathol. 2011 Oct;64(10):866-9
pubmed: 21725042
Mod Pathol. 2018 Jan;31(1):111-121
pubmed: 28884744
Hum Pathol. 2015 Mar;46(3):471-5
pubmed: 25543160
Lung Cancer. 2017 Jul;109:92-100
pubmed: 28577958
Lancet. 1989 Oct 28;2(8670):1038
pubmed: 2572764
Lung Cancer. 2012 Apr;76(1):51-5
pubmed: 21978426
Hum Pathol. 2016 Sep;55:11-6
pubmed: 27137985
Diagn Pathol. 2015 Dec 08;10:210
pubmed: 26643918
Histopathology. 2018 Feb;72(3):423-432
pubmed: 28914964
Mod Pathol. 2010 May;23(5):654-61
pubmed: 20173733
Virchows Arch. 2014 Nov;465(5):559-65
pubmed: 25059847
Acta Cytol. 2013;57(3):281-90
pubmed: 23635388
Am J Surg Pathol. 2011 Jun;35(6):816-26
pubmed: 21552115
Am J Surg Pathol. 2004 Apr;28(4):442-52
pubmed: 15087663
Int J Cancer. 1998 Feb 9;75(4):649-53
pubmed: 9466670
Virchows Arch. 2013 Dec;463(6):749-54
pubmed: 24126803
Hum Pathol. 2009 Jun;40(6):854-60
pubmed: 19269006
Histopathology. 2005 Feb;46(2):195-201
pubmed: 15693892
Mod Pathol. 2019 Jan;32(1):100-109
pubmed: 30154579
Hum Pathol. 1995 Apr;26(4):440-9
pubmed: 7705824
Acta Cytol. 2012;56(4):419-24
pubmed: 22846197
Cancer. 2011 Aug 1;117(15):3416-23
pubmed: 21246522
Am J Clin Pathol. 2004 Mar;121(3):350-7
pubmed: 15023039
Arch Pathol Lab Med. 2014 Aug;138(8):1067-71
pubmed: 25076295
Mod Pathol. 2017 Jun;30(6):797-809
pubmed: 28256572
Mod Pathol. 2007 Feb;20(2):233-41
pubmed: 17192789
Hum Pathol. 2018 Jan;71:84-90
pubmed: 29104109
Am J Clin Pathol. 2004 Sep;122(3):421-7
pubmed: 15362373
Adv Anat Pathol. 2016 Jan;23(1):13-23
pubmed: 26645458
Histopathology. 2011 Feb;58(3):467-76
pubmed: 21348892
Arch Pathol Lab Med. 2012 Feb;136(2):155-62
pubmed: 22288962
Cancer Res. 2000 Aug 1;60(15):4005-9
pubmed: 10945598
Adv Anat Pathol. 2014 Nov;21(6):394-410
pubmed: 25299309
Cancer Cytopathol. 2015 Feb;123(2):117-22
pubmed: 25529354
J Clin Pathol. 2016 Feb;69(2):136-41
pubmed: 26281863
Arch Pathol Lab Med. 2012 Feb;136(2):163-71
pubmed: 22288963
Am J Surg Pathol. 2009 Jul;33(7):984-91
pubmed: 19363441
Mod Pathol. 2017 Dec;30(12):1720-1727
pubmed: 28776576
Am J Surg Pathol. 2011 Dec;35(12):1830-6
pubmed: 21881489
Cancer Cytopathol. 2016 Feb;124(2):89-100
pubmed: 26882197
Appl Immunohistochem Mol Morphol. 2014;22(2):119-24
pubmed: 23531851
Lung Cancer. 2017 Jan;103:24-26
pubmed: 28024692
J Thorac Oncol. 2015 Sep;10(9):1243-1260
pubmed: 26291008
Am J Surg Pathol. 1995 Feb;19(2):173-82
pubmed: 7832277
Head Neck Pathol. 2013 Mar;7(1):35-9
pubmed: 23459839
Mod Pathol. 2006 Aug;19(8):1117-23
pubmed: 16680154
Appl Immunohistochem Mol Morphol. 2015 Jul;23(6):416-21
pubmed: 25356948
Cytojournal. 2014 Mar 20;11:7
pubmed: 24799951
Nat Rev Cancer. 2007 Oct;7(10):778-90
pubmed: 17882278
Hum Pathol. 2015 Jul;46(7):957-62
pubmed: 25971546
Arch Pathol Lab Med. 2012 Nov;136(11):1339-46
pubmed: 23106579
J Clin Oncol. 2004 Oct 15;22(20):4135-9
pubmed: 15483023
Chest. 2005 Jul;128(1):140-4
pubmed: 16002927