Contrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders.
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
28
04
2018
revised:
28
11
2018
accepted:
30
11
2018
pubmed:
21
12
2018
medline:
28
3
2020
entrez:
21
12
2018
Statut:
ppublish
Résumé
Anhedonia is a transdiagnostic construct that can occur independent of other symptoms of depression; its role in neuropsychiatric disorders that are not primarily affective, such as obsessive compulsive disorder (OCD), hoarding disorder (HD), and post-traumatic stress disorder (PTSD) has received limited attention. This paper addresses this gap. First, the data revealed a positive contribution of anhedonia, beyond the effects of general depression, to symptom severity in OCD but not in HD or PTSD. Second, anhedonia was operationalized as a reduced sensitivity to rewards, which allowed employing the value based decision making framework to investigate effects of anhedonia on reward-related behavioral outcomes, such as increased risk aversion and increased difficulty of making value-based choices. Both self-report and behavior-based measures were used to characterize individual risk aversion: risk perception and risk-taking propensities (measured using the Domain Specific Risk Taking scale) and risk attitudes evaluated using a gambling task. Data revealed the positive theoretically predicted correlation between anhedonia and risk perception in OCD; effects on self-reported risk taking and behavior-based risk aversion were non-significant. The same relations were weaker in HD and absent in PTSD. Response time during a gambling task, an index of difficulty of making value-based choices, significantly correlated with anhedonia in individuals with OCD and individuals with HD, even after controlling for general depression, but not in individuals with PTSD. The results suggest a unique contribution of one aspect of anhedonia in obsessive-compulsive disorder and confirm the importance of investigating the role of anhedonia transdiagnostically beyond affective and psychotic disorders.
Identifiants
pubmed: 30572276
pii: S0022-3956(18)30543-0
doi: 10.1016/j.jpsychires.2018.11.029
pmc: PMC8549853
mid: NIHMS1027962
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
202-213Subventions
Organisme : NIMH NIH HHS
ID : K01 MH101326
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH095790
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH102634
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH019961
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.
Références
Sci Rep. 2017 Mar 10;7:44374
pubmed: 28281665
Arch Gen Psychiatry. 2010 May;67(5):480-8
pubmed: 20439829
Mem Cognit. 1988 Mar;16(2):176-85
pubmed: 3352523
Trends Neurosci. 2003 Aug;26(8):423-8
pubmed: 12900173
J Clin Psychiatry. 2002 Dec;63(12):1106-12
pubmed: 12523869
J Anxiety Disord. 2011 Jan;25(1):43-8
pubmed: 20800427
Soc Sci Med. 2005 Mar;60(6):1385-96
pubmed: 15626532
Schizophr Bull. 2012 Sep;38(5):967-80
pubmed: 21415225
Biol Psychiatry. 2010 Mar 1;67(5):439-45
pubmed: 20034615
Comput Psychiatr. 2017;1(1):208-233
pubmed: 29400358
Depress Anxiety. 2011 Oct 3;28(10):876-84
pubmed: 21770000
Am J Psychiatry. 2010 Jul;167(7):748-51
pubmed: 20595427
Behav Res Ther. 2007 Nov;45(11):2754-63
pubmed: 17868641
Psychol Rep. 2014 Feb;114(1):185-97
pubmed: 24765720
Psychopharmacology (Berl). 2009 Sep;205(4):667-77
pubmed: 19529923
Neurosci Biobehav Rev. 2011 Jan;35(3):537-55
pubmed: 20603146
Psychiatry Res. 2003 Aug 1;119(3):243-50
pubmed: 12914895
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17143-8
pubmed: 24082105
J Abnorm Psychol. 2015 Nov;124(4):878-89
pubmed: 26214708
J Psychiatr Res. 2015 Oct;69:166-73
pubmed: 26343609
J Neurophysiol. 2010 Feb;103(2):1036-47
pubmed: 20032238
J Abnorm Child Psychol. 2016 Apr;44(3):483-94
pubmed: 26105209
Curr Opin Psychiatry. 2015 Jan;28(1):7-12
pubmed: 25415499
Arch Gen Psychiatry. 1989 Nov;46(11):1006-11
pubmed: 2684084
Acta Psychiatr Scand. 2001 Feb;103(2):122-30
pubmed: 11167315
J Psychopharmacol. 2007 Jul;21(5):461-71
pubmed: 17050654
Assessment. 2018 Jan;25(1):3-13
pubmed: 26988404
Cereb Cortex. 2014 Dec;24(12):3116-30
pubmed: 23825317
J Abnorm Psychol. 2017 Jul;126(5):694-711
pubmed: 28406662
Arch Gen Psychiatry. 2007 Mar;64(3):327-37
pubmed: 17339521
Dialogues Clin Neurosci. 2015 Dec;17(4):421-34
pubmed: 26869843
Biol Psychiatry. 2013 Feb 15;73(4):321-8
pubmed: 23200527
Biol Mood Anxiety Disord. 2013 Jun 19;3(1):12
pubmed: 23782813
Psychiatry Res. 2017 Dec;258:305-315
pubmed: 28864119
Neurosci Biobehav Rev. 2015 Apr;51:189-204
pubmed: 25639225
Biol Psychiatry. 2014 Apr 15;75(8):595-605
pubmed: 24314349
Front Psychol. 2012 Apr 25;3:125
pubmed: 22539930
Arch Gen Psychiatry. 2009 Nov;66(11):1189-200
pubmed: 19884607
Nat Rev Neurosci. 2008 Jul;9(7):545-56
pubmed: 18545266
Nat Rev Neurosci. 2013 Sep;14(9):609-25
pubmed: 23942470
J Anxiety Disord. 2003;17(2):233-42
pubmed: 12614665
Psychiatry Res. 2014 May 15;216(2):223-9
pubmed: 24564999
Br J Psychiatry. 2009 Sep;195(3):211-7
pubmed: 19721109
Depress Anxiety. 2016 Jul;33(7):606-613
pubmed: 27000639
Schizophr Bull. 2017 Jul 1;43(4):701-705
pubmed: 28969354
Behav Res Ther. 2006 Mar;44(3):457-67
pubmed: 16446151
J Anxiety Disord. 2011 Aug;25(6):840-8
pubmed: 21596518
J Psychopharmacol. 2013 Oct;27(10):869-77
pubmed: 23904408
Science. 2015 May 1;348(6234):499-500
pubmed: 25931539
Curr Dir Psychol Sci. 2013 Jun 1;22(3):244-249
pubmed: 24748727
Arch Gen Psychiatry. 1989 Nov;46(11):1012-6
pubmed: 2510699
J Gen Intern Med. 2007 Jun;22(6):711-8
pubmed: 17503104
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Sep;1(5):460-473
pubmed: 27833939
J Clin Psychol. 2006 Dec;62(12):1545-58
pubmed: 17019674
Behav Res Ther. 2004 Oct;42(10):1163-82
pubmed: 15350856