The epidemiology and severity of respiratory viral infections in a tropical country: Ecuador, 2009-2016.
Adolescent
Adult
Age Factors
Aged
Child
Child, Preschool
Ecuador
/ epidemiology
Female
Humans
Infant
Infant, Newborn
Influenza A Virus, H1N1 Subtype
/ isolation & purification
Male
Metapneumovirus
/ isolation & purification
Middle Aged
Population Surveillance
Respiratory Syncytial Virus, Human
/ isolation & purification
Respiratory Tract Infections
/ epidemiology
Retrospective Studies
Risk Factors
Seasons
Severity of Illness Index
Tropical Climate
Young Adult
Age distribution
Case-fatality ratio
Ecuador
Epidemiology
Respiratory viral infections
Journal
Journal of infection and public health
ISSN: 1876-035X
Titre abrégé: J Infect Public Health
Pays: England
ID NLM: 101487384
Informations de publication
Date de publication:
Historique:
received:
22
08
2018
revised:
16
11
2018
accepted:
06
12
2018
pubmed:
24
12
2018
medline:
18
6
2019
entrez:
22
12
2018
Statut:
ppublish
Résumé
Respiratory viral infections (RVI) are a leading cause of mortality worldwide. We compared the epidemiology and severity of RVI in Ecuador during 2009-2016. Respiratory specimens collected within the national surveillance system were tested for influenza viruses, respiratory syncytial virus (RSV), adenovirus, parainfluenza virus, and human metapneumovirus. Overall and virus-specific positive detection rate (PDR) were calculated and compared the timing of epidemics caused by the different viruses. Logistic regression models were used to compare the age distribution and risk of death across respiratory viruses. A total of 41,172 specimens were analyzed: influenza (PDR=14.3%) and respiratory syncytial virus (RSV) (PDR=9.5%) were the most frequently detected viruses. Influenza epidemics typically peaked in December-January and RSV epidemics in March; seasonality was less evident for the other viruses. Compared to adults, children were more frequently infected with RSV, adenovirus, parainfluenza, and influenza B, while the elderly were less frequently infected with influenza A(H1N1)p. The age-adjusted risk of death was highest for A(H1N1)p (odds ratio [OR] 1.73, 95% confidence intervals [CI] 1.38-2.17), and lowest for RSV (OR 0.75, 95%CI 0.57-0.98). Whilst influenza and RSV were the most frequently detected pathogens, the risk of death differed by RVI, being highest for pandemic influenza and lowest for RSV.
Sections du résumé
BACKGROUND
BACKGROUND
Respiratory viral infections (RVI) are a leading cause of mortality worldwide. We compared the epidemiology and severity of RVI in Ecuador during 2009-2016.
METHODS
METHODS
Respiratory specimens collected within the national surveillance system were tested for influenza viruses, respiratory syncytial virus (RSV), adenovirus, parainfluenza virus, and human metapneumovirus. Overall and virus-specific positive detection rate (PDR) were calculated and compared the timing of epidemics caused by the different viruses. Logistic regression models were used to compare the age distribution and risk of death across respiratory viruses.
RESULTS
RESULTS
A total of 41,172 specimens were analyzed: influenza (PDR=14.3%) and respiratory syncytial virus (RSV) (PDR=9.5%) were the most frequently detected viruses. Influenza epidemics typically peaked in December-January and RSV epidemics in March; seasonality was less evident for the other viruses. Compared to adults, children were more frequently infected with RSV, adenovirus, parainfluenza, and influenza B, while the elderly were less frequently infected with influenza A(H1N1)p. The age-adjusted risk of death was highest for A(H1N1)p (odds ratio [OR] 1.73, 95% confidence intervals [CI] 1.38-2.17), and lowest for RSV (OR 0.75, 95%CI 0.57-0.98).
CONCLUSIONS
CONCLUSIONS
Whilst influenza and RSV were the most frequently detected pathogens, the risk of death differed by RVI, being highest for pandemic influenza and lowest for RSV.
Identifiants
pubmed: 30573330
pii: S1876-0341(18)30320-4
doi: 10.1016/j.jiph.2018.12.003
pmc: PMC7102740
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
357-363Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
Virol J. 2013 May 07;10:143
pubmed: 23651577
PLoS One. 2014 Apr 03;9(4):e93632
pubmed: 24699432
Euro Surveill. 2009 Oct 08;14(40):
pubmed: 19822124
J Infect Dis. 2015 Dec 1;212(11):1701-10
pubmed: 25943206
Epidemiol Infect. 2015 Apr;143(6):1110-8
pubmed: 25307020
J Clin Lab Anal. 2018 Feb;32(2):
pubmed: 28397965
Viruses. 2016 Jan 11;8(1):
pubmed: 26761027
Clin Transl Sci. 2011 Feb;4(1):48-54
pubmed: 21348956
Curr Top Microbiol Immunol. 2013;372:39-57
pubmed: 24362683
BMC Infect Dis. 2013 Jun 20;13:281
pubmed: 23786598
Curr Top Microbiol Immunol. 2013;372:155-71
pubmed: 24362689
PLoS One. 2016 Mar 31;11(3):e0152310
pubmed: 27031105
Math Biosci. 2001 Aug;172(2):95-113
pubmed: 11520501
PLoS One. 2015 Oct 06;10(10):e0139958
pubmed: 26440103
Braz J Infect Dis. 2015 Jan-Feb;19(1):30-5
pubmed: 25307684
Influenza Other Respir Viruses. 2015 Nov;9(6):315-322
pubmed: 25980749
PLoS One. 2017 Mar 27;12(3):e0174592
pubmed: 28346498
PLoS One. 2017 May 3;12(5):e0176298
pubmed: 28467515
Nat Microbiol. 2017 Jan 30;2:16272
pubmed: 28134915
Clin Microbiol Infect. 2016 Feb;22(2):208.e1-208.e6
pubmed: 26482269
Influenza Other Respir Viruses. 2016 May;10(3):170-5
pubmed: 26701079
Curr Opin Infect Dis. 2017 Dec;30(6):573-578
pubmed: 29095723
Lancet Infect Dis. 2017 Nov;17(11):1133-1161
pubmed: 28843578
Influenza Other Respir Viruses. 2013 Nov;7 Suppl 3:36-43
pubmed: 24215380
Influenza Other Respir Viruses. 2018 Nov;12(6):780-792
pubmed: 29858537
Influenza Other Respir Viruses. 2016 Jan;10(1):14-26
pubmed: 26369646
J Clin Microbiol. 2006 Jul;44(7):2382-8
pubmed: 16825353
Lancet. 2011 Apr 9;377(9773):1264-75
pubmed: 21435708
BMC Infect Dis. 2012 Jan 17;12:7
pubmed: 22251705
Influenza Other Respir Viruses. 2014 Jul;8(4):397-405
pubmed: 24852890
Clin Microbiol Rev. 2000 Jan;13(1):1-15, table of contents
pubmed: 10627488
Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13396-400
pubmed: 26460003
BMC Infect Dis. 2017 Dec 16;17(1):772
pubmed: 29246199