Genetic susceptibility to radiation-induced breast cancer after Hodgkin lymphoma.
Adult
Aged
Aged, 80 and over
Breast Neoplasms
/ etiology
Cancer Survivors
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Hodgkin Disease
/ complications
Humans
Middle Aged
Neoplasms, Radiation-Induced
/ genetics
Neoplasms, Second Primary
/ genetics
Odds Ratio
Polymorphism, Single Nucleotide
Quality Control
Radiotherapy Dosage
Regression Analysis
Risk
Young Adult
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
07 03 2019
07 03 2019
Historique:
received:
09
07
2018
accepted:
12
12
2018
pmc-release:
07
03
2020
pubmed:
24
12
2018
medline:
13
11
2019
entrez:
22
12
2018
Statut:
ppublish
Résumé
Female Hodgkin lymphoma (HL) patients treated with chest radiotherapy (RT) have a very high risk of breast cancer. The contribution of genetic factors to this risk is unclear. We therefore examined 211 155 germline single-nucleotide polymorphisms (SNPs) for gene-radiation interaction on breast cancer risk in a case-only analysis including 327 breast cancer patients after chest RT for HL and 4671 first primary breast cancer patients. Nine SNPs showed statistically significant interaction with RT on breast cancer risk (false discovery rate, <20%), of which 1 SNP in the
Identifiants
pubmed: 30573632
pii: S0006-4971(20)42731-4
doi: 10.1182/blood-2018-07-862607
pmc: PMC6405334
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1130-1139Subventions
Organisme : Cancer Research UK
ID : 10119
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 10124
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14105
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U24 CA055727
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 by The American Society of Hematology.
Références
JAMA. 2017 Jun 20;317(23):2402-2416
pubmed: 28632866
Lancet Oncol. 2013 Dec;14(13):e621-9
pubmed: 24275135
Nat Med. 2011 Jul 24;17(8):941-3
pubmed: 21785431
J Clin Oncol. 2012 Aug 1;30(22):2745-52
pubmed: 22734026
Blood. 2011 Jul 21;118(3):670-4
pubmed: 21596858
J Clin Oncol. 1999 Apr;17(4):1259
pubmed: 10561187
Int J Epidemiol. 2018 Apr 1;47(2):526-536
pubmed: 29315403
Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2007-11
pubmed: 18708391
J Natl Cancer Inst. 1993 Jan 6;85(1):25-31
pubmed: 8416252
Br J Cancer. 2013 Jun 11;108(11):2399-406
pubmed: 23652303
Breast Cancer Res Treat. 2009 Nov;118(1):177-84
pubmed: 19214745
Int J Radiat Oncol Biol Phys. 2001 Feb 1;49(2):539-46
pubmed: 11173152
Nat Genet. 2017 Dec;49(12):1767-1778
pubmed: 29058716
Int J Cancer. 2008 Jan 1;122(1):177-82
pubmed: 17764108
Nat Genet. 2013 Apr;45(4):353-61, 361e1-2
pubmed: 23535729
J Clin Oncol. 2009 Aug 20;27(24):3901-7
pubmed: 19620485
J Clin Oncol. 2007 Apr 20;25(12):1489-97
pubmed: 17372278
J Clin Oncol. 2000 Feb;18(3):487-97
pubmed: 10653864
J Natl Cancer Inst. 2015 Apr 08;107(5):
pubmed: 25855707
J Natl Cancer Inst. 2017 Nov 1;109(11):
pubmed: 29059430
Ann Intern Med. 2004 Oct 19;141(8):590-7
pubmed: 15492338
PLoS Genet. 2013 Mar;9(3):e1003348
pubmed: 23555274
J Clin Oncol. 2003 Dec 15;21(24):4505-9
pubmed: 14673037
J Biol Chem. 2012 Jan 20;287(4):2509-19
pubmed: 22110125
Int J Radiat Biol. 2000 May;76(5):693-8
pubmed: 10866292
Cancer Causes Control. 2010 Nov;21(11):1857-66
pubmed: 20711808
Radiat Res. 2018 Mar;189(3):251-263
pubmed: 29309266
Int J Radiat Oncol Biol Phys. 2017 Nov 15;99(4):843-853
pubmed: 28888722
Br J Cancer. 2010 Sep 28;103(7):1081-4
pubmed: 20842115
Eur J Cancer. 2007 Oct;43(15):2144-52
pubmed: 17764928
Radiat Res. 2010 Feb;173(2):214-24
pubmed: 20095854
Int J Cancer. 2016 Sep 15;139(6):1303-1317
pubmed: 27087578
Stat Med. 1994 Jan 30;13(2):153-62
pubmed: 8122051
Br J Cancer. 2005 Sep 19;93(6):699-708
pubmed: 16222315
N Engl J Med. 2015 Dec 24;373(26):2499-511
pubmed: 26699166
J Clin Oncol. 2010 Dec 1;28(34):5088-96
pubmed: 20975072
Ann Oncol. 2014 Apr;25(4):848-51
pubmed: 24608191
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
J Clin Oncol. 2014 Jul 20;32(21):2217-23
pubmed: 24752044
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Nat Genet. 2010 Dec;42(12):1126-1130
pubmed: 21037568
Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2000-7
pubmed: 17932347
Mol Cancer Res. 2008 Feb;6(2):212-21
pubmed: 18314482
J Natl Cancer Inst. 2005 Oct 5;97(19):1428-37
pubmed: 16204692
J Clin Oncol. 2003 Dec 1;21(23):4386-94
pubmed: 14645429
J Natl Cancer Inst. 2003 Jul 2;95(13):971-80
pubmed: 12837833
Breast Cancer Res Treat. 2016 Aug;158(3):463-9
pubmed: 27438779
Int J Cancer. 2008 Dec 1;123(11):2713-6
pubmed: 18767034
Nature. 2017 Nov 2;551(7678):92-94
pubmed: 29059683
Cancer. 1997 Mar 15;79(6):1203-10
pubmed: 9070499
Blood. 2002 Sep 15;100(6):1989-96
pubmed: 12200357
J Clin Oncol. 2009 Sep 10;27(26):4239-46
pubmed: 19667275
Blood. 2012 Jan 26;119(4):1029-31
pubmed: 22144180
J Natl Cancer Inst. 2017 Jul 1;109(7):
pubmed: 28376175