Impact of Early Diabetic Ketoacidosis on the Developing Brain.
Age of Onset
Brain
/ diagnostic imaging
Case-Control Studies
Child
Child, Preschool
Cognition
/ physiology
Cognition Disorders
/ diagnosis
Diabetes Mellitus, Type 1
/ complications
Diabetic Ketoacidosis
/ diagnosis
Female
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Severity of Illness Index
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
02
07
2018
accepted:
19
11
2018
pubmed:
24
12
2018
medline:
31
10
2019
entrez:
22
12
2018
Statut:
ppublish
Résumé
This study examined whether a history of diabetic ketoacidosis (DKA) is associated with changes in longitudinal cognitive and brain development in young children with type 1 diabetes. Cognitive and brain imaging data were analyzed from 144 children with type 1 diabetes, ages 4 to <10 years, who participated in an observational study of the Diabetes Research in Children Network (DirecNet). Participants were grouped according to history of DKA severity (none/mild or moderate/severe). Each participant had unsedated MRI scans and cognitive testing at baseline and 18 months. In 48 of 51 subjects, the DKA event occurred at the time of onset, at an average of 2.9 years before study entry. The moderate/severe DKA group gained more total and regional white and gray matter volume over the observed 18 months compared with the none/mild group. When matched by age at time of enrollment and average HbA A single episode of moderate/severe DKA in young children at diagnosis is associated with lower cognitive scores and altered brain growth. Further studies are needed to assess whether earlier diagnosis of type 1 diabetes and prevention of DKA may reduce the long-term effect of ketoacidosis on the developing brain.
Identifiants
pubmed: 30573652
pii: dc18-1405
doi: 10.2337/dc18-1405
pmc: PMC6385695
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
443-449Subventions
Organisme : NICHD NIH HHS
ID : R01 HD078463
Pays : United States
Organisme : NICHD NIH HHS
ID : U10 HD041918
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Investigateurs
Eva Tsalikian
(E)
Michael J Tansey
(MJ)
Julie Coffey
(J)
Joanne Cabbage
(J)
Sara Salamati
(S)
Nelly Mauras
(N)
Larry A Fox
(LA)
Allison Cato
(A)
Kim Englert
(K)
Kaitlin Sikes
(K)
Bruce A Buckingham
(BA)
Darrell M Wilson
(DM)
Tandy Aye
(T)
Kimberly Caswell
(K)
Ellen Ambers
(E)
Stuart A Weinzimer
(SA)
William V Tamborlane
(WV)
Amy Steffen
(A)
Kate Weyman
(K)
Melinda Zgorski
(M)
Jodie Ambrosino
(J)
Neil H White
(NH)
Ana Maria Arbelaez
(AM)
Lucy Levandoski
(L)
Angie Starnes
(A)
Tamara Hershey
(T)
Allan L Reiss
(AL)
Naama Barnea-Goraly
(N)
Matthew J Marzelli
(MJ)
Paul K Mazaika
(PK)
Daniel X Peng
(DX)
Roy Beck
(R)
Craig Kollman
(C)
Katrina Ruedy
(K)
Karen Winer
(K)
Mark Sperling
(M)
Dorothy M Becker
(DM)
Patricia Cleary
(P)
Carla Greenbaum
(C)
Antoinette Moran
(A)
Informations de copyright
© 2018 by the American Diabetes Association.
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