Clinical and histologic outcome in a dog surviving massive hepatic necrosis.
acute
canine
hemoabdomen
histology
liver failure
shock
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
28
06
2018
accepted:
16
11
2018
pubmed:
24
12
2018
medline:
30
4
2019
entrez:
22
12
2018
Statut:
ppublish
Résumé
This report describes the clinical and histologic recovery of a 2-year-old mixed-breed dog presented with hypovolemic shock, markedly increased serum alanine amino transferase activity, and hemoabdomen. Emergency exploratory surgery revealed a friable liver with multiple capsule hemorrhages necessitating removal of the left lateral lobe. Histologic evaluation showed acute massive hepatic necrosis with centrilobular and midzonal distribution. The dog survived, and all monitored laboratory values normalized within 7 weeks. A liver biopsy taken 8 weeks after presentation revealed normal hepatic architecture with a few, randomly distributed neutrophilic foci. Follow-up included intermittent determination of liver variables including liver function tests for a period of 7 years. The dog's health status, and all test results remained normal during this time. Complete recovery and good long-term quality of life after life-threatening acute liver failure secondary to massive hepatic necrosis is possible in dogs.
Identifiants
pubmed: 30575127
doi: 10.1111/jvim.15391
pmc: PMC6430912
doi:
Substances chimiques
CD13 Antigens
EC 3.4.11.2
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
879-884Informations de copyright
© 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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