Method for the Direct Enantioselective Synthesis of Chiral Primary α-Amino Ketones by Catalytic α-Amination.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
04 01 2019
04 01 2019
Historique:
pubmed:
24
12
2018
medline:
24
12
2018
entrez:
22
12
2018
Statut:
ppublish
Résumé
A useful catalytic enantioselective approach has been developed for the synthesis of chiral ketamine analogs using Rh(II)-catalyzed amination of triisopropylsilyl enol ethers to form α-amino ketones with O-(4-nitrophenyl)hydroxylamine as nitrogen donor in 81-91% ee.
Identifiants
pubmed: 30576160
doi: 10.1021/acs.orglett.8b03733
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng