MicroRNA 146a Polymorphisms and Expression in Indian Children with Acute Lymphoblastic Leukemia.
childhood ALL
haplotype analysis
miR 146 expression
microRNA
rs2910164
rs57095329
Journal
Laboratory medicine
ISSN: 1943-7730
Titre abrégé: Lab Med
Pays: England
ID NLM: 0250641
Informations de publication
Date de publication:
16 Jul 2019
16 Jul 2019
Historique:
pubmed:
24
12
2018
medline:
18
12
2019
entrez:
22
12
2018
Statut:
ppublish
Résumé
MicroRNAs (miR) have been reported to be involved in hematopoiesis and in the pathogenesis of several hematological malignant neoplasms. Single-nucleotide polymorphisms (SNPs) in human miR genes may alter the expression of those genes and influence the predisposition to childhood leukemia. To evaluate the association of rs2910164 G>C, rs57095329 A>G and the expression of miRNA-146a in ethnic South Asian children with acute lymphoblastic leukemia (ALL). Genotyping and expression analysis using TaqMan Small RNA Assay was performed on 71 patients with pathologically confirmed ALL and 74 control individuals. No statistically significant association was found between the 2 SNPs, its expression levels, and ALL risk. Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
Sections du résumé
BACKGROUND
BACKGROUND
MicroRNAs (miR) have been reported to be involved in hematopoiesis and in the pathogenesis of several hematological malignant neoplasms. Single-nucleotide polymorphisms (SNPs) in human miR genes may alter the expression of those genes and influence the predisposition to childhood leukemia.
OBJECTIVE
OBJECTIVE
To evaluate the association of rs2910164 G>C, rs57095329 A>G and the expression of miRNA-146a in ethnic South Asian children with acute lymphoblastic leukemia (ALL).
METHOD
METHODS
Genotyping and expression analysis using TaqMan Small RNA Assay was performed on 71 patients with pathologically confirmed ALL and 74 control individuals.
RESULTS
RESULTS
No statistically significant association was found between the 2 SNPs, its expression levels, and ALL risk.
CONCLUSION
CONCLUSIONS
Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
Identifiants
pubmed: 30576465
pii: 5255654
doi: 10.1093/labmed/lmy074
doi:
Substances chimiques
MIRN146 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
249-253Informations de copyright
© American Society for Clinical Pathology 2018. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.