In-vitro evaluation on drug release kinetics and antibacterial activity of dextran modified polyurethane fibrous membrane.
3T3 Cells
Adsorption
Animals
Anti-Bacterial Agents
/ pharmacology
Blood Platelets
/ ultrastructure
Curcumin
/ pharmacology
Dextrans
/ chemistry
Drug Liberation
Fibroblasts
/ cytology
Humans
Hydrogen-Ion Concentration
Kinetics
Mice
Microbial Sensitivity Tests
Platelet Adhesiveness
/ drug effects
Polyurethanes
/ chemistry
Porosity
Serum Albumin, Bovine
/ metabolism
Solvents
Spectroscopy, Fourier Transform Infrared
Staphylococcus aureus
/ drug effects
Steam
Thermogravimetry
Wettability
X-Ray Diffraction
Curcumin bioavailability
Dextran
Electrospinning
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
01 Apr 2019
01 Apr 2019
Historique:
received:
31
10
2018
revised:
07
12
2018
accepted:
17
12
2018
pubmed:
24
12
2018
medline:
1
6
2019
entrez:
22
12
2018
Statut:
ppublish
Résumé
pH stimuli drug release nanofibrous membranes of polyurethane/dextran were developed for tailoring of antibacterial wound dressings. Incorporation of dextran in polyurethane (PU) showed increment in hydrophilicity, vapour transmission rate, percentage sorption values, and biodegradability. Dextran also acts as reinforcement filler in PU matrix. Dextran induces a high degree of platelet adhesion and hemostasis potential which is essential for promoting the wound healing process. Moreover, 20 wt% dextran loaded membranes (PU/20D) exhibited enhanced cell proliferation, attachment and viability against 3T3 fibroblasts. Curcumin loaded PU/20 dextran membrane exhibited pH-controlled drug release potency and synergistic antibacterial activity against gram-positive bacteria. It is confirmed that, PU/20D membranes could promote, pH-controlled drug release and synergistic antibacterial activity for a promising wound dressing material.
Identifiants
pubmed: 30576735
pii: S0141-8130(18)35892-6
doi: 10.1016/j.ijbiomac.2018.12.155
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Dextrans
0
Polyurethanes
0
Solvents
0
Steam
0
Serum Albumin, Bovine
27432CM55Q
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
717-730Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.